NCBI and Uniprot Product Information
Uniprot Description
IL21: Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation. Belongs to the IL-15/IL-21 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell development/differentiation; Cytokine; Secreted; Secreted, signal peptide; Apoptosis
Cellular Component: extracellular region; extracellular space; intracellular
Molecular Function: cytokine activity; hematopoietin/interferon-class (D200-domain) cytokine receptor binding; interleukin-2 receptor binding
Biological Process: B cell apoptosis; cell maturation; immune response; positive regulation of B cell differentiation; positive regulation of B cell proliferation; positive regulation of cell proliferation; positive regulation of cytokine production; positive regulation of interferon-gamma biosynthetic process; positive regulation of interleukin-10 production; positive regulation of interleukin-17 production; positive regulation of natural killer cell cytokine production; positive regulation of natural killer cell differentiation; positive regulation of natural killer cell mediated cytotoxicity; positive regulation of T cell proliferation; positive regulation of tyrosine phosphorylation of Stat1 protein; positive regulation of tyrosine phosphorylation of Stat3 protein; tyrosine phosphorylation of Stat3 protein
Research Articles on Il21
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Product Notes
The Mouse Il21 il21 (Catalog #AAA2880237) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2880237 ELISA Kit recognizes Mouse Il21. It is sometimes possible for the material contained within the vial of "Interleukin-21, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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