IL-1 Receptor Antagonist Protein/IL-1ra/IL-1RA Recombinant Protein | IL-1ra/IL-1RA recombinant protein
Recombinant Mouse IL-1 Receptor Antagonist Protein/IL-1ra/IL-1RA Protein
Gene Names
Il1rn; IL-1ra; F630041P17Rik
Purity
>95% as determined by reducing SDS-PAGE.
Synonyms
IL-1 Receptor Antagonist Protein/IL-1ra/IL-1RA; Recombinant Mouse IL-1 Receptor Antagonist Protein/IL-1ra/IL-1RA Protein; IL-1RN; IL-1ra; IRAP; IL1 inhibitor; Il1rn; Interleukin-1 Receptor Antagonist Protein; IL-1ra/IL-1RA recombinant protein
Host
E Coli
Purity/Purification
>95% as determined by reducing SDS-PAGE.
Form/Format
Lyophilized from a 0.2 mum filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Sequence Positions
Arg27-Gln178
Sequence Length
178
Species
Mouse
Endotoxin
<1.0 EU per mug as determined by LAL test.
Preparation and Storage
Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.
Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.
Related Product Information for IL-1ra/IL-1RA recombinant protein
Interleukin-1 receptor antagonist protein (Il1rn), also known as IL-1ra, IRAP or IL1 inhibitor, is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1 alpha (IL1A) and interleukin 1 beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. The mouse Il1rn gene encodes a 178 amino acids (aa) protein with a 26 aa signal peptide. Mouse Il1rn protein shares 26% and 19% identity with its homologues IL-1 beta and IL-1 alpha, respectively. Il1rn can Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling, but has no interleukin-1 like activity. Recently, an recombinant human Il1rn protein is used in the treatment of rheumatoid arthritis, an autoimmune disease in which IL-1 plays a key role.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
Molecular Mass: 17.5 kDa
Actual Protein Molecular Mass: 16 kDa
Actual Protein Molecular Mass: 16 kDa
NCBI Official Full Name
interleukin-1 receptor antagonist protein isoform 2
NCBI Official Synonym Full Names
interleukin 1 receptor antagonist
NCBI Official Symbol
Il1rn
NCBI Official Synonym Symbols
IL-1ra; F630041P17Rik
NCBI Protein Information
interleukin-1 receptor antagonist protein
UniProt Protein Name
Interleukin-1 receptor antagonist protein
UniProt Gene Name
Il1rn
UniProt Synonym Gene Names
Il-1ra; IL-1RN; IL-1ra; IRAP
Uniprot Description
Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity.
Research Articles on IL-1ra/IL-1RA
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Product Notes
The IL-1ra/IL-1RA il1rn (Catalog #AAA2553521) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is Arg27-Gln178. It is sometimes possible for the material contained within the vial of "IL-1 Receptor Antagonist Protein/IL-1ra/IL-1RA, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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