IL-1 receptor type II (CD121b) Recombinant Protein | IL1R2 recombinant protein

Rat IL-1 receptor type II Recombinant (CD121b)

Cat. Num. AAA553257

• Purity: >97%, as determined by SDS-PAGE and HPLC
• Synonyms: IL-1 receptor type II (CD121b); Rat IL-1 receptor type II Recombinant (CD121b); Rat IL-1 receptor type II Recombinant ; CD121B; D2S1473; IL-1R2; IL-1RB; IL1R2; IL1RB; P80; IL1R2 recombinant protein

• Host: HEk293 Cells
• Purity/Purification: >97%, as determined by SDS-PAGE and HPLC
• Form/Format: Recombinant Rat IL-1 receptor II (CD121b) is lyophilized from 0.2 um filtered PBS solution, pH7.2, 5% Trehalose.
• Sequence Length: 416

• Domain: Ig-like C2
• Host Note: Optimized DNA sequence encoding Rat extracellular domain of Rat IL-1 receptor type II including a C-terminal His tag was expressed in HEK293 cells.
• Molecular Weight Note: Recombinant rat IL-R2 (CD121b) is a protein consisting of 353 amino acid residue subunits, due to glycosylation migrates as an approximately 90 kDa protein on SDS-PAGE.
• Preparation and Storage: Recombinant Rat IL1R2 can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C to -70 degree C for twelve months.; ; Avoid repeated freeze/thaw cycles.

Related Product Information for IL1R2 recombinant protein

Two distinct IL-lRs have been identified, termed type I and type II. The type I IL-lR is an 80-kDa glycoprotein found predominantly on T cells and fibroblasts, whereas the type II IL-lR is a 60- to 65-kDa molecule that is expressed on activated T cells, B cells, monocytes, and neutrophils. Evidence suggests that the type II IL-lR is not signal- transducing, and its function on the cell surface is unknown. The action of IL-1 is modulated not only by IL-lra but also by the release of a type II soluble IL-iR (sIL-lR). This 47-kDa soluble receptor is present in normal human plasma, serum, and synovial inflammatory exudate and in culture supernatants of activated peripheral blood mononuclear cells and neutrophils. sIL-lR is also released from the human B-cell Burkitt lymphoma cell line Raji, which expresses only type II IL-1R.

Product Categories/Family for IL1R2 recombinant protein

Receptors CD

References

• pellino 2 is critical for toll-like receptor/interleukin-1 receptor (tlr/IL-1R) -mediated post-transcriptional control .J. Biol. Chem., Jul 2012; 287: 25686 - 25695.
• role of toll interleukin-1 receptor (IL-1R) 8, a negative regulator of IL-1R/toll-like receptor signaling, in resistance to acute pseudomonas aeruginosa lung infection .Infect. Immun., Jan 2012; 80: 100 - 109.
• IL-1R–associated kinase-1 mediates protein kinase c-induced il-1β production in monocytes .J. Immunol., Sep 2011; 187: 2632 - 2645.
• effect of mitomycin c on IL-1R expression, il-1–related hepatocyte growth factor secretion and corneal epithelial cell migration .Invest. Ophthalmol. Vis. Sci., Mar 2010; 51: 1389 - 1396.
• mycobacterium bovis bacillus calmette-guérin vaccination mobilizes innate myeloid-derived suppressor cells restraining in vivo t cell priming via IL-1R–dependent nitric oxide production .J. Immunol., Feb 2010; 184: 2038 - 2047.