IL-18 Receptor Accessory Protein/IL-18RAcP/IL-1R7 Recombinant Protein | IL-18RAcP/IL-1R7 recombinant protein

Recombinant Human IL-18 Receptor Accessory Protein/IL-18RAcP/IL-1R7 Protein (C-6His)

Cat. Num. AAA2552791

• Gene Names: IL18RAP; ACPL; CD218b; IL-1R7; IL18RB; CDw218b; IL-1R-7; IL-18RAcP; IL-1RAcPL; IL-18Rbeta; IL-18R-beta
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: IL-18 Receptor Accessory Protein/IL-18RAcP/IL-1R7; Recombinant Human IL-18 Receptor Accessory Protein/IL-18RAcP/IL-1R7 Protein (C-6His); Interleukin-18 receptor accessory protein (IL18RAP); Accessory protein-like; CD218 antigen-like family member B; CDw218b; IL-1R accessory protein-like; Interleukin-1 receptor 7; Interleukin-18 receptor accessory protein-like; Interleukin-18 receptor beta?¨CD218b and IL1R7; IL-18RAcP/IL-1R7 recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of PBS, pH 7.4.
• Sequence Positions: Phe20-Arg356
• Sequence Length: 599

• Species: Human
• Endotoxin: <1.0 EU per ug as determined by LAL test.
• Fusion Tag: C-6His
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for IL-18RAcP/IL-1R7 recombinant protein

IL-18RAP is a single-pass type I membrane protein and contains two Ig-like C2-type domains and one TIR domain, IL18RAP can be induced by IFN-alpha and IL12 in nature killer cells and T-cells. The coexpression of IL18R1 and IL18RAP is required for the activation of NF-kappa B and JNK in response to IL-18.Defects in IL18RAP are associated with Coeliac disease.

NCBI and Uniprot Product Information

• NCBI GI #: 4504657
• NCBI GeneID: 8807
• NCBI Accession #: NP_003844.1
• NCBI GenBank Nucleotide #: NM_003853.3
• UniProt Accession #: O95256; Q2QDE5; Q3KPE7; Q3KPE8; Q53TT4; Q53TU5; B2RPJ3
• Molecular Weight: Molecular Mass: 39.4 kDa; Actual Protein Molecular Mass: 56 kDa
• NCBI Official Full Name: interleukin-18 receptor accessory protein
• NCBI Official Synonym Full Names: interleukin 18 receptor accessory protein
• NCBI Official Symbol: IL18RAP
• NCBI Official Synonym Symbols: ACPL; CD218b; IL-1R7; IL18RB; CDw218b; IL-1R-7; IL-18RAcP; IL-1RAcPL; IL-18Rbeta; IL-18R-beta
• NCBI Protein Information: interleukin-18 receptor accessory protein
• UniProt Protein Name: Interleukin-18 receptor accessory protein
• UniProt Gene Name: IL18RAP
• UniProt Synonym Gene Names: IL-1RAcPL; IL-1R-7; IL-1R7; IL-18R-beta; IL-18Rbeta3 PublicationsManual assertion based on opinion iniRef.7

NCBI Description

The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for interleukin 18 (IL18), a proinflammatory cytokine involved in inducing cell-mediated immunity. This protein enhances the IL18-binding activity of the IL18 receptor and plays a role in signaling by IL18. Mutations in this gene are associated with Crohn's disease and inflammatory bowel disease, and susceptibility to celiac disease and leprosy. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]

Uniprot Description

Within the IL18 receptor complex, does not mediate IL18-binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activation (PubMed:9792649, PubMed:14528293, PubMed:25500532). May play a role in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (Probable).