IL-17RC Recombinant Protein | IL17RC recombinant protein

Human IL-17RC Recombinant

Cat. Num. AAA553299

• Purity: >98%, as determined by SDS-PAGE and HPLC
• Synonyms: IL-17RC; Human IL-17RC Recombinant; il-17rc; il17RC; interleukin-17 r; IL17RC recombinant protein

• Host: HEk293 Cells
• Purity/Purification: >98%, as determined by SDS-PAGE and HPLC
• Form/Format: Recombinant Interleukin-17RC is supplied as lyophilized 0.2 um filtered PBS solution, pH7.2.
• Sequence Length: 707

• Host Note: Optimized DNA sequence encoding extracellular domain of human IL-17RC receptor including a C terminal His tag was expressed in HEK293 cells.
• Endotoxin: Endotoxin content was assayed using a LAL gel clot method.; Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).
• Molecular Weight Note: Recombinant IL17RC is a monomer protein consisting of 444 amino acid residue subunits, due to glycosylation migrates as an approximately 50kD protein under reducing SDS-PAGE conditions.
• Preparation and Storage: Recombinant IL-17RC, as supplied, can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C to -70 degree C for twelve months.; ; Avoid repeated freeze/thaw cycles.

Related Product Information for IL17RC recombinant protein

IL-17 is a potent regulator of the neutrophil response. Both IL-17A and IL-17F are capable of signaling through IL-17RA to induce granulopoietic factors such as G-CSF and stem cell factor which leads to expansion of neutrophil progenitors in the bone marrow and spleen, as well as expansion of mature neutrophils in peripheral blood. IL-17RA signaling up- regulates production of neutrophilic chemokines such as CXCL1 (KC), CXCL2, CXCL5, CXCL6, and CXCL8, which in turn regulate neutrophil emigration to mucosal sites. Due to this role in neutrophil expansion and recruitment, IL-17RA signaling is an important part of the host response to extracellular bacterial infections.To date, four additional receptors have been identified in the IL- 17R family based on sequence homology to IL-17R (IL- 17Rh1, IL-17RC, IL-17RD, and IL-17RE) and among them, IL- 17RC has been shown recently to physically associate with IL-17RA, suggesting that it may be a functional component in the IL-17R complex. Nevertheless, the final structure of the functional IL-17 receptor and the mechanisms of interactions with IL-17A remain unknown.

Product Categories/Family for IL17RC recombinant protein

Receptors CD

References

• il-17a and IL-17RC expression in the macula of the human eye with age-related macular degeneration .Invest. Ophthalmol. Vis. Sci., Mar 2012; 53: 1667.
• il-17a- versus il-17f-induced intracellular signal transduction pathways and modulation by il-17ra and IL-17RC rna interference in rheumatoid synoviocytes .Ann Rheum Dis, Feb 2011; 70: 341 - 348.
• IL-17RC is required for immune signaling via an extended sef/il-17r signaling domain in the cytoplasmic tail .J. Immunol., Jul 2010; 185: 1063 - 1070.
• IL-17RC is required for il-17a– and il-17f–dependent signaling and the pathogenesis of experimental autoimmune encephalomyelitis .J. Immunol., Apr 2010; 184: 4307 - 4316.
• the human il-17f/il-17a heterodimeric cytokine signals through the il-17ra/IL-17RC receptor complex .J. Immunol., Aug 2008; 181: 2799 - 2805.