IL17B/IL-17B recombinant protein

Recombinant Human IL17B/IL-17B Protein (C-Fc)

Cat. Num. AAA2557237

• Gene Names: IL17B; NIRF; IL-20; IL-17B; ZCYTO7
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: IL17B/IL-17B; Recombinant Human IL17B/IL-17B Protein (C-Fc); cytokine Zcyto7; IL-17B; interleukin-17 beta; interleukin-17B; neuronal interleukin-17 related factor; Neuronal interleukin-17-related factor; NIRF; ZCYTO7interleukin-Cytokine Zcyto7; cytokine-like protein ZCYTO7; interleukin 17B; Neuronal interleukin-17-related factor;; IL17B/IL-17B recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of 20mM PB, 150mM NaCl, pH7.4.
• Sequence: Gln21-Phe180
• Sequence Length: 180

• Species: Human
• Endotoxin: < 1.0 EU per mug as determined by the LAL method.
• Fusion Tag: C-Fc
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for IL17B/IL-17B recombinant protein

Protein Construction: Recombinant Human Interleukin-17B is produced by our mammalian expression system and the target gene encoding Gln21-Phe180 is expressed with a Fc tag at the C-terminus.

Background: Interleukin-17B (IL-17B) is a member of IL-17 cytokines family that plays important roles in host defence responses and inflammatory diseases. In addition to IL-17B, members of the IL-17 family include IL-17A, IL-17C, IL-17D, IL-17E and IL-17F. The six IL-17 cytokines are highly conserved at C terminus, and contain five spatially conserved cysteine residues that mediate dimerization. Expression of IL-17B protein has been reported in neurons, testis, ovary, stomach, pancreas, small intestine and chondrocytes. IL-17B binds to Interleukine-17 receptor B (IL-17 RB) and induces the production of inflammatory cytokines and the infiltration of inflammatory immune cells.

NCBI and Uniprot Product Information

• NCBI GI #: 7657228
• NCBI GeneID: 27190
• NCBI Accession #: NP_055258.1
• NCBI GenBank Nucleotide #: NP_055258.1
• UniProt Accession #: Q9UHF5
• Molecular Weight: Molecular Mass: 45.1kDa; Actual Protein Molecular Mass: 48kDa
• NCBI Official Full Name: interleukin-17B isoform 1
• NCBI Official Synonym Full Names: interleukin 17B
• NCBI Official Symbol: IL17B
• NCBI Official Synonym Symbols: NIRF; IL-20; IL-17B; ZCYTO7
• NCBI Protein Information: interleukin-17B
• UniProt Protein Name: Interleukin-17B
• UniProt Gene Name: IL17B
• UniProt Synonym Gene Names: IL20; NIRF; ZCYTO7; IL-17B; IL-20
• UniProt Entry Name: IL17B_HUMAN

NCBI Description

The protein encoded by this gene is a T cell-derived cytokine that shares sequence similarity with IL17. This cytokine was reported to stimulate the release of TNF alpha (TNF) and IL1 beta (IL1B) from a monocytic cell line. Immunohistochemical analysis of several nerve tissues indicated that this cytokine is primarily localized to neuronal cell bodies. Alternative splicing results in multiple splice variants. [provided by RefSeq, Dec 2015]

Uniprot Description

IL17B: Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1. Belongs to the IL-17 family.

Protein type: Secreted; Secreted, signal peptide; Cytokine

Chromosomal Location of Human Ortholog: 5q33.1

Cellular Component: extracellular space

Molecular Function: cytokine activity

Biological Process: cell-cell signaling; immune response; inflammatory response