IL-13 alpha 2 receptor (IL13RA2) Recombinant Protein | IL13RA2 recombinant protein
Mouse IL-13 alpha 2 receptor Recombinant (IL13RA2)
Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).
Avoid repeated freeze/thaw cycles.
• IL-13R2 membrane and soluble isoforms differ in humans and mice .J. Immunol., Dec 2009; 183: 7870 - 7876.
• tuning sensitivity to il-4 and il-13: differential expression of il-4r, IL-13R1, and c regulates relative cytokine sensitivity .J. Exp. Med., Oct 2008; 205: 2595 - 2608.
• novel role of il-13 in fibrosis induced by nonalcoholic steatohepatitis and its amelioration by IL-13R-directed cytotoxin in a rat model .J. Immunol., Oct 2008; 181: 4656 - 4665.
• targeting IL-13R2-positive cancer with a novel recombinant immunotoxin composed of a single-chain antibody and mutated pseudomonas exotoxin .Mol. Cancer Ther., Jun 2008; 7: 1579 - 1587.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a receptor protein that binds to interleukin 13 (IL-13) with very high affinity. The encoded protein acts as a decoy receptor, and does not elicit any signal upon the binding of IL-13. Mice lacking the encoded protein exhibit increased levels of serum immunoglobulins, immune-dependent production of interferon gamma and, increased bone marrow macrophage progenitor frequency. Macrophages lacking the encoded protein release less nitric oxide and IL-12 in response to lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
Uniprot Description
IL13RA2: a type I membrane protein that binds with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4). Lacks a cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13. A member of the Cancer-Testis Antigen (CTA) superfamily. CTAs may play roles in embryonal development and tumor transformation or aspects of tumor progression. CTAs were once thought to be silenced in most normal adult tissues, with limited expression in fetal, placental, testis, and ovarian cells. These proteins are now known to be aberrantly expressed in various cancers and many are capable of eliciting humoral and cellular immune responses. The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box 1 motif is required for JAK interaction and/or activation. Often overexpressed in brain tumors. A potential vaccine targets for immunotherapy of glioma. Note: This description may include information from RefSeq and UniProtKB
Protein type: Receptor, cytokine; Cancer Testis Antigen (CTA); Membrane protein, integral
Cellular Component: membrane; extracellular region; integral to membrane
Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity
Biological Process: negative regulation of mast cell degranulation; negative regulation of immunoglobulin production; immunoglobulin mediated immune response
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Product Notes
The IL13RA2 il13ra2 (Catalog #AAA553325) is a Recombinant Protein produced from HEk293 Cells and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "IL-13 alpha 2 receptor (IL13RA2), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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