Interleukin-12 receptor subunit beta-2 (Il12rb2) Recombinant Protein | Il12rb2 recombinant protein
Recombinant Mouse Interleukin-12 receptor subunit beta-2 (Il12rb2), partial
Gene Names
Il12rb2; Ifnm; IL-12RB2; A930027I18Rik
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
Interleukin-12 receptor subunit beta-2 (Il12rb2); Recombinant Mouse Interleukin-12 receptor subunit beta-2 (Il12rb2); partial; Il12rb2 recombinant protein
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Positions
24-637
Sequence
NIDVCKL GTVTVQPAPV IPLGSAANIS CSLNPKQGCS HYPSSNELIL LKFVNDVLVE NLHGKKVHDH TGHSSTFQVT NLSLGMTLFV CKLNCSNSQK KPPVPVCGVE ISVGVAPEPP QNISCVQEGE NGTVACSWNS GKVTYLKTNY TLQLSGPNNL TCQKQCFSDN RQNCNRLDLG INLSPDLAES RFIVRVTAIN DLGNSSSLPH TFTFLDIVIP LPPWDIRINF LNASGSRGTL QWEDEGQVVL NQLRYQPLNS TSWNMVNATN AKGKYDLRDL RPFTEYEFQI SSKLHLSGGS WSNWSESLRT RTPEEEPVGI LDIWYMKQDI DYDRQQISLF WKSLNPSEAR GKILHYQVTL QEVTKKTTLQ NTTRHTSWTR VIPRTGAWTA SVSAANSKGA SAPTHINIVD LCGTGLLAPH QVSAKSENMD NILVTWQPPK KADSAVREYI VEWRALQPGS ITKFPPHWLR IPPDNMSALI SENIKPYICY EIRVHALSES QGGCSSIRGD SKHKAPVSGP HITAITEKKE RLFISWTHIP FPEQRGCILH YRIYWKERDS TAQPELCEIQ YRRSQNSHPI SSLQPRVTYV LWMTAVTAAG ESPQGNEREF CPQGKAN
Sequence Length
614
Species
Mouse
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Related Product Information for Il12rb2 recombinant protein
This protein is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn s disease and leprosy, which is thought to contribute to the inflammatory response and host defense.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
98,197 Da
NCBI Official Full Name
interleukin-12 receptor subunit beta-2 isoform 2
NCBI Official Synonym Full Names
interleukin 12 receptor, beta 2
NCBI Official Symbol
Il12rb2
NCBI Official Synonym Symbols
Ifnm; IL-12RB2; A930027I18Rik
NCBI Protein Information
interleukin-12 receptor subunit beta-2
UniProt Protein Name
Interleukin-12 receptor subunit beta-2
Protein Family
UniProt Gene Name
Il12rb2
UniProt Synonym Gene Names
IL-12 receptor subunit beta-2; IL-12R subunit beta-2; IL-12R-beta-2; IL-12RB2
Uniprot Description
Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production. Can also activate STAT3.
Research Articles on Il12rb2
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Product Notes
The Il12rb2 il12rb2 (Catalog #AAA963614) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 24-637. The amino acid sequence is listed below: NIDVCKL GTVTVQPAPV IPLGSAANIS CSLNPKQGCS HYPSSNELIL LKFVNDVLVE NLHGKKVHDH TGHSSTFQVT NLSLGMTLFV CKLNCSNSQK KPPVPVCGVE ISVGVAPEPP QNISCVQEGE NGTVACSWNS GKVTYLKTNY TLQLSGPNNL TCQKQCFSDN RQNCNRLDLG INLSPDLAES RFIVRVTAIN DLGNSSSLPH TFTFLDIVIP LPPWDIRINF LNASGSRGTL QWEDEGQVVL NQLRYQPLNS TSWNMVNATN AKGKYDLRDL RPFTEYEFQI SSKLHLSGGS WSNWSESLRT RTPEEEPVGI LDIWYMKQDI DYDRQQISLF WKSLNPSEAR GKILHYQVTL QEVTKKTTLQ NTTRHTSWTR VIPRTGAWTA SVSAANSKGA SAPTHINIVD LCGTGLLAPH QVSAKSENMD NILVTWQPPK KADSAVREYI VEWRALQPGS ITKFPPHWLR IPPDNMSALI SENIKPYICY EIRVHALSES QGGCSSIRGD SKHKAPVSGP HITAITEKKE RLFISWTHIP FPEQRGCILH YRIYWKERDS TAQPELCEIQ YRRSQNSHPI SSLQPRVTYV LWMTAVTAAG ESPQGNEREF CPQGKAN. It is sometimes possible for the material contained within the vial of "Interleukin-12 receptor subunit beta-2 (Il12rb2), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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