IKKB (S701) Blocking Peptide | Ikbkb blocking peptide

Phospho-mouse IKKB(S701) Blocking Peptide

• Gene Names: Ikbkb; IKK2; IKK-2; IKK[b]; IKKbeta; AI132552; IKK-beta
• Synonyms: IKKB (S701); Phospho-mouse IKKB(S701) Blocking Peptide; Inhibitor of nuclear factor kappa-B kinase subunit beta; I-kappa-B-kinase beta; IKK-B; IKK-beta; IkBKB; I-kappa-B kinase 2; IKK2; Nuclear factor NF-kappa-B inhibitor kinase beta; NFKBIKB; Ikbkb; Ikkb; Ikbkb blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 696-707 of MOUSE Ikbkb
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 738

• Cellular Location: Cytoplasm. Nucleus. Membrane raft. Note: Colocalized with DPP4 in membrane rafts.
• Tissue Location: Expressed in liver, kidney and spleen.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for Ikbkb blocking peptide

Serine kinase that plays an essential role in the NF- kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 33469101
• NCBI GeneID: 16150
• NCBI Accession #: NP_034676.1
• NCBI GenBank Nucleotide #: NM_010546.2
• UniProt Accession #: O88351; Q9R1J6
• Molecular Weight: 86,690 Da
• NCBI Official Full Name: inhibitor of nuclear factor kappa-B kinase subunit beta isoform 2
• NCBI Official Synonym Full Names: inhibitor of kappaB kinase beta
• NCBI Official Symbol: Ikbkb
• NCBI Official Synonym Symbols: IKK2; IKK-2; IKK[b]; IKKbeta; AI132552; IKK-beta
• NCBI Protein Information: inhibitor of nuclear factor kappa-B kinase subunit beta
• UniProt Protein Name: Inhibitor of nuclear factor kappa-B kinase subunit beta
• UniProt Gene Name: Ikbkb
• UniProt Synonym Gene Names: Ikkb; I-kappa-B-kinase beta; IKK-B; IKK-beta; IkBKB; IKK2; NFKBIKB
• UniProt Entry Name: IKKB_MOUSE

Uniprot Description

IKKB: a kinase of the IKK family. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Preferentially found as a heterodimer with IKK-alpha but also as an homodimer.

Protein type: EC 2.7.11.10; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, Other; Other group; IKK family

Cellular Component: cytoplasm; cytosol; IkappaB kinase complex; internal side of plasma membrane; intracellular membrane-bound organelle

Molecular Function: ATP binding; IkappaB kinase activity; protein binding; protein heterodimerization activity; protein homodimerization activity; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; receptor signaling protein serine/threonine kinase activity

Biological Process: activation of NF-kappaB transcription factor; B cell homeostasis; cortical actin cytoskeleton organization and biogenesis; I-kappaB kinase/NF-kappaB cascade; I-kappaB phosphorylation; neurite development; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; regulation of phosphorylation; serine phosphorylation of STAT protein; tumor necrosis factor-mediated signaling pathway