Rabbit Insulin Like Growth Factor Binding Protein 3 ELISA Kit | IGFBP3 elisa kit
Rabbit Insulin Like Growth Factor Binding Protein 3 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
an insulin growth factor (Igf) binding protein; involved in modulating IGF-I action [RGD, Feb 2006]
Uniprot Description
IGFBP3: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R.
Protein type: Secreted, signal peptide; Secreted; Cell development/differentiation
Cellular Component: extracellular space; nucleus
Molecular Function: insulin-like growth factor binding; protein binding; insulin-like growth factor I binding; fibronectin binding; insulin-like growth factor II binding; protein tyrosine phosphatase activator activity
Biological Process: positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of catalytic activity; osteoblast differentiation; negative regulation of cell proliferation; regulation of insulin-like growth factor receptor signaling pathway; negative regulation of protein amino acid phosphorylation; positive regulation of MAPKKK cascade; positive regulation of apoptosis; negative regulation of smooth muscle cell proliferation; regulation of growth; negative regulation of smooth muscle cell migration; regulation of cell growth; protein amino acid phosphorylation; positive regulation of myoblast differentiation