IMP1 / ZBP1 Blocking Peptide | IGF2BP1 blocking peptide
IMP1 / ZBP1 Immunizing Peptide
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the insulin-like growth factor 2 mRNA-binding protein family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs of certain genes, including insulin-like growth factor 2, beta-actin and beta-transducin repeat-containing protein, and regulating their translation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Uniprot Description
IGF2BP1: a conserved trans-acting factor that can control translation of specific mRNAs in vivo. Contains four K homology (KH) domains and two RNA recognition motifs. It functions by binding to the 5' UTR of the target mRNAs and repressing translation. Target mRNAs include those encoding beta-actin and insulin-like growth factor 2 (IGF2). Tyrosine phosphorylation apparently abolishes translational repression of actin expression by decreasing its binding beta-actin mRNA. May have a role in progression of ovarian cancer. Contains nuclear export signals within the RNA-binding KH2 and KH4 domains. Aberrant expression may interfere with c-myc regulation.
Protein type: Translation; RNA-binding
Chromosomal Location of Human Ortholog: 17q21.32
Cellular Component: axon; cytoplasm; cytosol; dendritic spine; filopodium; growth cone; lamellipodium; nucleus; perinuclear region of cytoplasm; ribonucleoprotein complex; stress granule
Molecular Function: mRNA 3'-UTR binding; mRNA 5'-UTR binding; mRNA binding; nucleotide binding; protein binding; translation regulator activity
Biological Process: gene expression; mRNA transport; negative regulation of translation; pallium cell proliferation in the forebrain; regulation of cytokine biosynthetic process
Research Articles on IGF2BP1
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Product Notes
The IGF2BP1 igf2bp1 (Catalog #AAA427271) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. The IMP1 / ZBP1 Immunizing Peptide reacts with Human, Mouse, Rat, Dog, Cow and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: C-EKVFAEHK ISYSGQ. It is sometimes possible for the material contained within the vial of "IMP1 / ZBP1, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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