Insulin-like growth factor 1 receptor Recombinant Protein | Igf1r recombinant protein

Insulin-like growth factor 1 receptor

Cat. Num. AAA7042889

• Gene Names: Igf1r; Igfr1; JTK13; IGFIRC; IGF-1 receptor
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Insulin-like growth factor 1 receptor; Igf1r recombinant protein

• Host: Cell Free Expression
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Liquid containing glycerol
• Sequence Positions: 31-737aa; full length protein
• Sequence: EICGPGIDIRNDYQQLKRLENCTVIEGFLHILLISKAEDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTIDWSLILDAVSNNYIVGNKPPKECGDLCPGTLEEKPMCEKTTINNEYNYRCWTTNRCQKMCPSVCGKRACTENNECCHPECLGSCHTPDDNTTCVACRHYYYKGVCVPACPPGTYRFEGWRCVDRDFCANIPNAESSDSDGFVIHDGECMQECPSGFIRNSTQSMYCIPCEGPCPKVCGDEEKKTKTIDSVTSAQMLQGCTILKGNLLINIRRGNNIASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWNHRNLTVRSGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLRFTSTTTWKNRIIITWHRYRPPDYRDLISFTVYYKEAPFKNVTEYDGQDACGSNSWNMVDVDLPPNKEGEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPTLPNGNLSYYIVRWQRQPQDGYLFRHNYCSKDKIPIRKYADGTIDVEEVTENPKTEVCGGDKGPCCACPKTEAEKQAEKEEAEYRKVFENFLHNSIFVPRPERRRRDVLQVANTTMSSRSRNTTVADTYNIT
• Sequence Length: Full Length Protein

• Species: Rattus norvegicus (Rat)
• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.; Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.

Related Product Information for Igf1r recombinant protein

This is a recombinant transmembrane protein expressed in a cell-free expression system.

Product Categories/Family for Igf1r recombinant protein

Transmembrane Protein

NCBI and Uniprot Product Information

• NCBI GI #: 16258823
• NCBI GeneID: 25718
• NCBI Accession #: NP_434694.1
• NCBI GenBank Nucleotide #: NM_052807.2
• UniProt Accession #: P24062
• Molecular Weight: 155,396 Da
• NCBI Official Full Name: insulin-like growth factor 1 receptor
• NCBI Official Synonym Full Names: insulin-like growth factor 1 receptor
• NCBI Official Symbol: Igf1r
• NCBI Official Synonym Symbols: Igfr1; JTK13; IGFIRC; IGF-1 receptor
• NCBI Protein Information: insulin-like growth factor 1 receptor
• UniProt Protein Name: Insulin-like growth factor 1 receptor
• Protein Family: Insulin-like growth factor 1 receptor
• UniProt Gene Name: Igf1r
• UniProt Synonym Gene Names: IGF-I receptor
• UniProt Entry Name: IGF1R_RAT

NCBI Description

receptor for Igf-1; involved in induction of cell cycle progression and survival in many cell types [RGD, Feb 2006]

Uniprot Description

IGF1R: a receptor tyrosine kinase that binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. Functions as an anti-apoptotic agent by enhancing cell survival. Can play a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand- binding domain, while the beta chain carries the kinase domain. Interacts with PIK3R1 and with the PTB/PID domains of IRS1 and SHC1 in vitro when autophosphorylated on tyrosine residues. Mutated in rare cases of pre- and post-natal growth retardation. One SNP associated with increased human longevity. Increased expression of IGF1R and other pathway members associated with progression and malignancy in a range of cancers. Inhibitors: AG1024, AEW541.

Protein type: Kinase, protein; EC 2.7.10.1; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group; InsR family

Cellular Component: axon; caveola; cell soma; cytoplasm; integral to membrane; intracellular membrane-bound organelle; membrane; neuron projection; nucleus; plasma membrane; receptor complex; T-tubule

Molecular Function: G-protein alpha-subunit binding; identical protein binding; insulin binding; insulin receptor binding; insulin receptor substrate binding; insulin-like growth factor binding; insulin-like growth factor I binding; insulin-like growth factor receptor activity; phosphoinositide 3-kinase binding; protein binding; protein-tyrosine kinase activity

Biological Process: adrenal gland development; aging; axonogenesis; brain development; cellular response to insulin stimulus; cerebellum development; epidermis development; establishment of cell polarity; exocrine pancreas development; hippocampus development; immune response; inactivation of MAPKK activity; insulin-like growth factor receptor signaling pathway; male sex determination; mammary gland development; negative regulation of apoptosis; negative regulation of MAPKKK cascade; negative regulation of protein kinase B signaling cascade; negative regulation of transcription factor activity; neurite development; organ morphogenesis; phosphoinositide-mediated signaling; positive regulation of axon regeneration; positive regulation of cell migration; positive regulation of cytokinesis; positive regulation of DNA metabolic process; positive regulation of DNA replication; positive regulation of MAPKKK cascade; positive regulation of meiotic cell cycle; positive regulation of mitosis; positive regulation of osteoblast proliferation; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein kinase B signaling cascade; positive regulation of smooth muscle cell proliferation; positive regulation of transcription, DNA-dependent; protein amino acid autophosphorylation; protein amino acid phosphorylation; protein heterooligomerization; protein tetramerization; regulation of JNK cascade; response to insulin stimulus; response to vitamin E