Insulin Like Growth Factor 1 Receptor (IGF1R) Recombinant Protein | IGF1R recombinant protein

Recombinant Insulin Like Growth Factor 1 Receptor (IGF1R)

Cat. Num. AAA2097676

• Gene Names: Igf1r; Igfr1; JTK13; IGFIRC; IGF-1 receptor
• Reactivity: Rat
• Applications: SDS-Page, Western Blot
• Purity: >90%
• Synonyms: Insulin Like Growth Factor 1 Receptor (IGF1R); Recombinant Insulin Like Growth Factor 1 Receptor (IGF1R); CD221; IGF1-R; IGFIR; JTK13; IGF1R recombinant protein

• Host: E Coli
• Reactivity: Rat
• Purity/Purification: >90%
• Form/Format: Freeze-dried powder
• Sequence Length: 1370

• Applicable Applications for IGF1R recombinant protein: Positive Control, Immunogen, SDS-PAGE, Western Blot (WB)
• Expression System: Prokaryotic expression
• Tag: N-terminal His Tag
• Buffer Formulation: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Endotoxin Level: <1.0EU per 1ug (determined by the LAL method)
• Fragment: Tyr764~Leu956

SDS-Page

Product Categories/Family for IGF1R recombinant protein

Signal transduction; Endocrinology; Cardiovascular biology; Hormone metabolism

NCBI and Uniprot Product Information

• NCBI GI #: 16258823
• NCBI GeneID: 25718
• NCBI Accession #: NP_434694.1
• NCBI GenBank Nucleotide #: NM_052807.2
• UniProt Accession #: P24062
• Molecular Weight: Predicted Molecular Weight: 25.7kDa
• NCBI Official Full Name: insulin-like growth factor 1 receptor
• NCBI Official Synonym Full Names: insulin-like growth factor 1 receptor
• NCBI Official Symbol: Igf1r
• NCBI Official Synonym Symbols: Igfr1; JTK13; IGFIRC; IGF-1 receptor
• NCBI Protein Information: insulin-like growth factor 1 receptor
• UniProt Protein Name: Insulin-like growth factor 1 receptor
• Protein Family: Insulin-like growth factor 1 receptor
• UniProt Gene Name: Igf1r
• UniProt Synonym Gene Names: IGF-I receptor

NCBI Description

receptor for Igf-1; involved in induction of cell cycle progression and survival in many cell types [RGD, Feb 2006]

Uniprot Description

IGF1R: a receptor tyrosine kinase that binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. Functions as an anti-apoptotic agent by enhancing cell survival. Can play a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand- binding domain, while the beta chain carries the kinase domain. Interacts with PIK3R1 and with the PTB/PID domains of IRS1 and SHC1 in vitro when autophosphorylated on tyrosine residues. Mutated in rare cases of pre- and post-natal growth retardation. One SNP associated with increased human longevity. Increased expression of IGF1R and other pathway members associated with progression and malignancy in a range of cancers. Inhibitors: AG1024, AEW541.

Protein type: EC 2.7.10.1; InsR family; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group

Chromosomal Location of Human Ortholog: 1q22

Cellular Component: axon; caveola; cell soma; cytoplasm; integral component of membrane; intracellular membrane-bound organelle; membrane; neuron projection; nucleus; plasma membrane; receptor complex; T-tubule

Molecular Function: ATP binding; G-protein alpha-subunit binding; identical protein binding; insulin binding; insulin receptor binding; insulin receptor substrate binding; insulin-like growth factor binding; insulin-like growth factor I binding; insulin-like growth factor-activated receptor activity; phosphoinositide 3-kinase binding; protein binding; protein tyrosine kinase activity

Biological Process: adrenal gland development; aging; axonogenesis; brain development; cardiac atrium development; cellular response to aldosterone; cellular response to amyloid-beta; cellular response to angiotensin; cellular response to dexamethasone stimulus; cellular response to estradiol stimulus; cellular response to glucose stimulus; cellular response to insulin stimulus; cellular response to insulin-like growth factor stimulus; cellular response to progesterone stimulus; cellular response to testosterone stimulus; cellular response to transforming growth factor beta stimulus; cellular senescence; cerebellum development; epidermis development; establishment of cell polarity; exocrine pancreas development; hippocampus development; immune response; inactivation of MAPKK activity; insulin receptor signaling pathway; insulin-like growth factor receptor signaling pathway; male sex determination; mammary gland development; negative regulation of apoptosis; negative regulation of cholangiocyte apoptotic process; negative regulation of hepatocyte apoptotic process; negative regulation of MAPKKK cascade; negative regulation of muscle cell apoptotic process; negative regulation of protein kinase B signaling cascade; negative regulation of transcription factor activity; neuron projection development; organ morphogenesis; peptidyl-tyrosine autophosphorylation; peptidyl-tyrosine phosphorylation; phosphoinositide-mediated signaling; positive regulation of axon regeneration; positive regulation of cell migration; positive regulation of cytokinesis; positive regulation of DNA metabolic process; positive regulation of DNA replication; positive regulation of MAPK cascade; positive regulation of meiotic cell cycle; positive regulation of mitotic nuclear division; positive regulation of osteoblast proliferation; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein complex disassembly; positive regulation of protein kinase B signaling; positive regulation of smooth muscle cell proliferation; positive regulation of steroid hormone biosynthetic process; positive regulation of transcription, DNA-templated; protein amino acid phosphorylation; protein autophosphorylation; protein heterooligomerization; protein tetramerization; regulation of JNK cascade; response to ethanol; response to insulin stimulus; response to L-glutamate; response to nicotine; response to nutrient levels; response to vitamin E