SDS-Page
(Recombinant Human IFN-alpha/beta R1 Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.)
IFN-alpha/beta R1 Recombinant Protein | IFN-alpha recombinant protein
Recombinant Human IFN-alpha/beta R1 Protein
After reconstitution, the protein solution is stable at -20 degree C for 3 months, at 2-8 degree C for up to 1 week.
SDS-Page
(Recombinant Human IFN-alpha/beta R1 Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.)
SDS-Page
(Recombinant Human IFN-alpha/beta R1 Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.)
Background: The Interferon-alpha/beta Receptor 1 (IFN-alpha/beta R1) is a receptor which binds Type I Interferons including Interferon-alphaand - beta. It is a cell surface receptor and heteromeric receptor composed of one chain with two subunitsreferred to as IFNAR1 and IFNAR2. IFN- alpha / beta R1, in association with IFN- alpha / beta R2, is required for propagatingantiviral signal transduction triggered by IFN- alpha and IFN- beta. IFN- alpha / beta R1 interacts very weakly or not at all withtype 1 interferons and does not stably interact with IFN- alpha / beta R2. Ligands associate with IFN- alpha / beta R2, and thiscomplex subsequently forms a stable ternary assembly with IFN-alpha/beta R1. IFN-alpha/beta R1 also associates with IFN-gammaR2 even in the absence of IFN- gamma stimulation. Human IFN- alpha / beta R1 contains a nuclear localization signal in itsextracellular domain that is required for receptor translocation to the nucleus following interaction withligand. Interferon stimulation results in an immunologic response that is especially associated with viruses.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. [provided by RefSeq, Jul 2008]
Uniprot Description
IFNAR1: receptor for interferons alpha and beta. Belongs to the type II cytokine family of receptors. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves. Tyk2 tyrosine kinase is essential for stable cell surface expression of IFNAR1. Present in all tissues and even on the surface of most IFN-resistant cells.
Protein type: Receptor, cytokine; Membrane protein, integral
Chromosomal Location of Human Ortholog: 21q22.11
Cellular Component: integral to plasma membrane; integral to membrane; plasma membrane
Molecular Function: protein binding; interferon receptor activity; interferon-alpha/beta receptor activity
Biological Process: positive regulation of interferon-gamma production; cell surface receptor linked signal transduction; T cell activation; response to virus; cytokine and chemokine mediated signaling pathway; positive regulation of interleukin-1 beta secretion; JAK-STAT cascade; interferon type I biosynthetic process; defense response to virus
Research Articles on IFN-alpha
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Product Notes
The IFN-alpha ifnar1 (Catalog #AAA9139948) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: KNLKSPQKVE VDIIDDNFIL RWNRSDESVG NVTFSFDYQK TGMDNWIKLS GCQNITSTKC NFSSLKLNVY EEIKLRIRAE KENTSSWYEV DSFTPFRKAQ IGPPEVHLEA EDKAIVIHIS PGTKDSVMWA LDGLSFTYSL VIWKNSSGVE ERIENIYSRH KIYKLSPETT YCLKVKAALL TSWKIGVYSP VHCIKTTVEN ELPPPENIEV SVQNQNYVLK WDYTYANMTF QVQWLHAFLK RNPGNHLYKW KQIPD. It is sometimes possible for the material contained within the vial of "IFN-alpha/beta R1, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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