IFN alpha 1b recombinant protein
IFN alpha 1b Protein (Active)
Applications
SDS-Page
Synonyms
IFN alpha 1b; IFN alpha 1b Protein (Active); Interferon alpha 1b; INFalpha 1b Protein (Active); INFa 1b Protein (Active); IFN alpha 1b recombinant protein
Host
E Coli
Form/Format
Lyophilized
Applicable Applications for IFN alpha 1b recombinant protein
HPLC, SDS-PAGE
Dimers
< 1% by SDS-PAGE
Endotoxin Level
< 0.1 ng/ug (1 EU/ug) by LAL test
Reconstitution
Reconstitute with sterile 18MΩ-cm H2O.
Storage Buffer
Each vial contains 10 mM Phosphate buffer and 200 mM NaCl (pH7.0) without preservatives.
Storage Buffer
Each vial contains 10 mM Phosphate buffer and 200 mM NaCl (pH7.0) without preservatives.
Preparation and Storage
Ship at 4 degree C. Upon receipt, aliquot and store at -20 degree C or -80 degree C for long term. Avoid repeated freeze and thaw cycles.
Related Product Information for IFN alpha 1b recombinant protein
Recombinant human INFα 1b protein with molecular weight 19.4 kDa.
IFN-alpha, a multifunctional cytokine important in the innate immune system, has been proposed to play a major pathogenic role in the development of systemic lupus erythematosus in humans and mice. IFNA bound complement component receptor-2 (CR2) in the same affinity range as other CR2 ligands. Asokan et al. (2006) proposed that the roles of CR2 and IFNA in development of autoimmunity may be mechanistically linked to pathogenesis of systemic lupus erythematosus. Interferon-alpha and -beta (IFN-alpha/beta) and the tumour suppressor p53 are essential for the induction of apoptosis in cancerous cells and in antiviral immune responses, respectively. The transcription of the p53 gene is induced by IFN-alpha/beta, accompanied by an increase in p53 protein level. IFN-alpha/beta signalling itself does not activate p53; rather, it contributes to boosting p53 responses to stress signals.
IFN-alpha, a multifunctional cytokine important in the innate immune system, has been proposed to play a major pathogenic role in the development of systemic lupus erythematosus in humans and mice. IFNA bound complement component receptor-2 (CR2) in the same affinity range as other CR2 ligands. Asokan et al. (2006) proposed that the roles of CR2 and IFNA in development of autoimmunity may be mechanistically linked to pathogenesis of systemic lupus erythematosus. Interferon-alpha and -beta (IFN-alpha/beta) and the tumour suppressor p53 are essential for the induction of apoptosis in cancerous cells and in antiviral immune responses, respectively. The transcription of the p53 gene is induced by IFN-alpha/beta, accompanied by an increase in p53 protein level. IFN-alpha/beta signalling itself does not activate p53; rather, it contributes to boosting p53 responses to stress signals.
References
1. Asokan, R., Hua, J., Young, K. A., Gould, H. J., Hannan, J. P., Kraus, D. M., Szakonyi, G., Grundy, G. J., Chen, X. S., Crow, M. K., Holers, V. M. Characterization of human complement receptor type 2 (CR2/CD21) as a receptor for IFN-alpha: a potential role in systemic lupus erythematosus. J. Immun. 177: 383-394, 2006. 2. Takaoka, A., Hayakawa, S., Yanai, H., Stolber, D., Negishi, H., Kikuchi, H., Sasaki, S., Imai, K., Shibue, T., Honda, K., Taniguchi, T. Integration of interferon-alpha/beta signalling to p53 responses in tumour suppression and antiviral defence. Nature 424: 516-523, 2003.
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Product Notes
The IFN alpha 1b (Catalog #AAA355610) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's IFN alpha 1b can be used in a range of immunoassay formats including, but not limited to, HPLC, SDS-PAGE. Researchers should empirically determine the suitability of the IFN alpha 1b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IFN alpha 1b, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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