Zinc-Alpha 2 Glycoprotein Native Protein | ZA2G native protein

Human Zinc-Alpha 2 Glycoprotein

Cat. Num. AAA145455

• Gene Names: AZGP1; ZAG; ZA2G
• Purity: Greater than 80% as determined by SDS-PAGE.
• Synonyms: Zinc-Alpha 2 Glycoprotein; Human Zinc-Alpha 2 Glycoprotein; ZA2G Human; Zinc-alpha 2 glycoprotein Human; Zn-alpha-2-glycoprotein; Zn-alpha-2-GP; AZGP1; ZAG; Zinc-alpha-2-glycoprotein; ZNGP1; ZA2G; ZA2G native protein

• Host: Human Serum
• Purity/Purification: Greater than 80% as determined by SDS-PAGE.
• Form/Format: ZA2G protein filtered (0.4 um) and lyophilized in 0.5mg/ml in 20mM TRIS and 50mM NaCl, pH 8.0.; Filtered White lyophilized (freeze-dried) powder.
• Sequence: QENQDGRYSL TYIYTGLSKH VEDVPAFQAL GSLNDLQFFR YNSKDRKSQP MGLWRQVEGM EDWKQDSQLQ KAREDIFMET LKDIVEYYND SNGSHVLQGR FGCEIENNRS SGAFWKYYYD GKDYIEFNKE IPAWVPFDPA AQITKQKWEA EPVYVQRAKA YLEEECPATL RKYLKYSKNI LDRQDPPSVV VTSHQAPGEK KKLKCLAYDF YPGKIDVHWT RAGEVQEPEL RGDVLHNGNG TYQSWVVVAV PPQDTAPYSC HVQHSSLAQP LVVPWEAS.
• Sequence Length: 298

• Preparation and Storage: Store lyophilized protein at -20 degree C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4 degree C for a limited period of time; it does not show any change after two weeks at 4 degree C.

Related Product Information for ZA2G native protein

Background/Introduction: Zinc-alpha-2-glycoprotein (ZAG) is found in body fluids such as serum, sweat, and seminal and breast cyst fluids. It is identical in amino acid sequence to tumor-derived lipid mobilizing factor (LMF), a protein associated with the dramatic loss of adipose body stores in cancer cachexia, and has been shown to stimulate lipolysis by adipocytes in vivo and in vitro. A role for ZAG has been proposed in the regulation of body weight, and age-dependent changes in genetically influenced obesity, and also it regulates melanin production by normal and malignant melanocytes. It has also recently been classified as a novel adipokine in that it is produced by both white and brown fat adipocytes and may act in a local autocrine fashion in the reduction of adiposity in cachexia. Controlling ZAG/LMF's activity could be life-saving in the management of certain cancers and other cachexiainducing conditions, and its possible normal role in body fat store homeostasis is deserving of understanding in its own right. ZAG exhibits a class I major histocompatibility complex (MHC) fold but is a soluble protein rather than being anchored to plasma membranes and does not associate with alpha- 2-microglobulin in humans. Like antigen-presenting MHC class I proteins, ZAG has an open apical groove, and X-ray crystallography of human derived ZAG revealed an unidentifiable electron density in a similar position to that occupied by antigenic peptides in classical MHC proteins and glycolipids in isoforms of CD1. This presumptive ligand is not a peptide, and the groove is too small to hold a glycolipid such as is presented by CD1 isoforms. By analogy with all other MHC class I-related proteins that have an open apical groove [some do not ], occupancy by a ligand is probably crucial to ZAG's biological function. Despite all of the structural and biochemical evidence that ZAG binds a ligand, none has so far been found by extraction from protein isolated from biological fluids. This difficulty could be because the ligand is labile, heterogeneous, or readily lost during purification procedures. Knowing more about how ZAG interacts with the compounds it has been found to bind, both natural and artificial, will inform searches for the elusive ligand(s) and its/their role in ZAG's signaling function.

Product Categories/Family for ZA2G native protein

Recombinant & Natural Proteins; Recombinant Proteins; Zinc Finger

NCBI and Uniprot Product Information

• NCBI GI #: 4502337
• NCBI GeneID: 563
• NCBI Accession #: NP_001176.1
• NCBI GenBank Nucleotide #: NM_001185.3
• UniProt Accession #: P25311; O60386; Q5XKQ4; Q8N4N0; D6W5T8
• Molecular Weight: 34,259 Da
• NCBI Official Full Name: zinc-alpha-2-glycoprotein
• NCBI Official Synonym Full Names: alpha-2-glycoprotein 1, zinc-binding
• NCBI Official Symbol: AZGP1
• NCBI Official Synonym Symbols: ZAG; ZA2G
• NCBI Protein Information: zinc-alpha-2-glycoprotein; Alpha-2-glycoprotein, zinc; Zn-alpha2-glycoprotein; zn-alpha-2-GP; zn-alpha-2-glycoprotein
• UniProt Protein Name: Zinc-alpha-2-glycoprotein
• UniProt Gene Name: AZGP1
• UniProt Synonym Gene Names: ZAG; ZNGP1; Zn-alpha-2-GP; Zn-alpha-2-glycoprotein
• UniProt Entry Name: ZA2G_HUMAN

Uniprot Description

AZGP1: Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. May bind polyunsaturated fatty acids. Belongs to the MHC class I family.

Protein type: Secreted; Secreted, signal peptide; Cell adhesion

Chromosomal Location of Human Ortholog: 7q22.1

Cellular Component: extracellular space; plasma membrane; extracellular region; MHC class I protein complex; nucleus

Molecular Function: peptide antigen binding; protein transmembrane transporter activity; glycoprotein binding; antigen binding; ribonuclease activity

Biological Process: retinal homeostasis; negative regulation of cell proliferation; antigen processing and presentation; antigen processing and presentation of peptide antigen via MHC class I; positive regulation of T cell mediated cytotoxicity; immune response; detection of chemical stimulus involved in sensory perception of bitter taste; cell adhesion