Human Natriuretic Peptide Receptor 2 (NPR2) RTU ELISA Kit | NPR2 rtu elisa kit

Human Natriuretic Peptide Receptor 2 (NPR2) ELISA Kit

Cat. Num. AAA4501435

• Gene Names: NPR2; AMDM; ANPb; ECDM; NPRB; SNSK; ANPRB; GUC2B; NPRBi; GUCY2B
• Reactivity: Human
• Synonyms: Natriuretic Peptide Receptor 2 (NPR2); Human Natriuretic Peptide Receptor 2 (NPR2) ELISA Kit; AMDM; ANPRB; ANPb; NPRBi; NPR-B; GUCY2B; GUC2B; Guanylate Cyclase B; Atrial natriuretic peptide receptor type B; NPR2 rtu elisa kit

• Reactivity: Human
• Sequence Length: 1047

• Assay Type: Sandwich
• Samples: Tissue Homogenates, Cell Lysates or Other Biological Fluids.
• Detection Range: 78.1-5000pg/mL
• Sensitivity: 29.5pg/mL
• RTU ELISA Kit's Advantage: The Ready-To-Use (RTU) Kits require fewer steps in setup and take less time to run. Detection Solutions are pre-diluted and total incubation time is shorter than many other ELISA Kits.
• Preparation and Storage: For unopened kits: All the reagents should be kept at 4 degree C upon receipt.; For opened kits: Once the kit is opened, the remaining reagents still need to be stored according to the above storage conditions. In addition, return the unused wells to the foil pouch containing the desiccant pack and reseal along entire edge of zip-seal.

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for NPR2 rtu elisa kit

Test Principle: The microtiter plate provided in this kit has been pre-coated with an antibody specific to NPR2. Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody preparation specific to NPR2. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain NPR2, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of NPR2 in the samples is then determined by comparing the O.D. of the samples to the standard curve.

NCBI and Uniprot Product Information

• NCBI GI #: 4580422
• NCBI GeneID: 4882
• NCBI Accession #: NP_003986.2
• NCBI GenBank Nucleotide #: NM_003995.3
• UniProt Accession #: P20594; O60871; Q4VAK7; Q5TCV2; Q8TA93; Q9UQ50; B0ZBF2; B0ZBF3; D3DRP3; D3DRP4
• Molecular Weight: 111,208 Da
• NCBI Official Full Name: atrial natriuretic peptide receptor 2
• NCBI Official Synonym Full Names: natriuretic peptide receptor 2
• NCBI Official Symbol: NPR2
• NCBI Official Synonym Symbols: AMDM; ANPb; ECDM; NPRB; SNSK; ANPRB; GUC2B; NPRBi; GUCY2B
• NCBI Protein Information: atrial natriuretic peptide receptor 2
• UniProt Protein Name: Atrial natriuretic peptide receptor 2
• Protein Family: Nitrogen permease regulator
• UniProt Gene Name: NPR2
• UniProt Synonym Gene Names: ANPRB; ANP-B; ANPR-B; NPR-B; GC-B

NCBI Description

This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type. [provided by RefSeq, Jul 2008]

Uniprot Description

Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth.