Human FK506 Binding Protein 5 (FKBP5) RTU ELISA Kit | FKBP5 rtu elisa kit

Human FK506 Binding Protein 5 (FKBP5) ELISA Kit

Cat. Num. AAA459343

• Gene Names: FKBP5; P54; AIG6; FKBP51; FKBP54; PPIase; Ptg-10
• Reactivity: Human
• Synonyms: FK506 Binding Protein 5 (FKBP5); Human FK506 Binding Protein 5 (FKBP5) ELISA Kit; P54; FKBP51; FKBP54; Ptg-10; Rotamase; 51 kDa FK506-binding protein; 54 kDa progesterone receptor-associated; Androgen-regulated protein 6; HSP90-binding immunophilin; FKBP5 rtu elisa kit

• Reactivity: Human
• Sequence Length: 457

• Assay Type: Sandwich
• Samples: Serum, Plasma, Tissue Homogenates or Other Biological Fluids.
• Detection Range: 0.156-10ng/mL
• Sensitivity: 0.061ng/mL
• RTU ELISA Kit's Advantage: The Ready-To-Use (RTU) Kits require fewer steps in setup and take less time to run. Detection Solutions are pre-diluted and total incubation time is shorter than many other ELISA Kits.
• Preparation and Storage: For unopened kits: All the reagents should be kept at 4 degree C upon receipt.; For opened kits: Once the kit is opened, the remaining reagents still need to be stored according to the above storage conditions. In addition, return the unused wells to the foil pouch containing the desiccant pack and reseal along entire edge of zip-seal.

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for FKBP5 rtu elisa kit

Test Principle: The microtiter plate provided in this kit has been pre-coated with an antibody specific to FKBP5. Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody preparation specific to FKBP5. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain FKBP5, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of FKBP5 in the samples is then determined by comparing the O.D. of the samples to the standard curve.

NCBI and Uniprot Product Information

• NCBI GI #: 224809327
• NCBI GeneID: 2289
• NCBI Accession #: NP_001139247.1
• NCBI GenBank Nucleotide #: NM_001145775.2
• UniProt Accession #: Q13451; Q59EB8; Q5TGM6; F5H7R1
• Molecular Weight: 30,032 Da
• NCBI Official Full Name: peptidyl-prolyl cis-trans isomerase FKBP5 isoform 1
• NCBI Official Synonym Full Names: FK506 binding protein 5
• NCBI Official Symbol: FKBP5
• NCBI Official Synonym Symbols: P54; AIG6; FKBP51; FKBP54; PPIase; Ptg-10
• NCBI Protein Information: peptidyl-prolyl cis-trans isomerase FKBP5
• UniProt Protein Name: Peptidyl-prolyl cis-trans isomerase FKBP5
• Protein Family: FK506-binding protein
• UniProt Gene Name: FKBP5
• UniProt Synonym Gene Names: AIG6; FKBP51; PPIase FKBP5; 51 kDa FKBP; FKBP-51; FKBP-5; p54

NCBI Description

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]

Uniprot Description

Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded.