Human Filamin C Gamma (FLNC) RTU ELISA Kit | FLNC rtu elisa kit

Human Filamin C Gamma (FLNC) ELISA Kit

Cat. Num. AAA459352

• Gene Names: FLNC; ABPA; ABPL; FLN2; MFM5; MPD4; RCM5; CMH26; ABP-280; ABP280A
• Reactivity: Human
• Synonyms: Filamin C Gamma (FLNC); Human Filamin C Gamma (FLNC) ELISA Kit; ABP-280; ABP280A; ABPA; ABPL; FLN2; Actin Binding Protein 280; ABP-280-like protein; Actin-binding-like protein; Filamin-2; FLNC rtu elisa kit

• Reactivity: Human
• Sequence Length: 2692

• Assay Type: Sandwich
• Samples: Serum, Plasma, Tissue Homogenates, Cell Lysates, Cell Culture Supernates or Other Biological Fluids.
• Detection Range: 0.312-20ng/mL
• Sensitivity: 0.126ng/mL
• RTU ELISA Kit's Advantage: The Ready-To-Use (RTU) Kits require fewer steps in setup and take less time to run. Detection Solutions are pre-diluted and total incubation time is shorter than many other ELISA Kits.
• Preparation and Storage: For unopened kits: All the reagents should be kept at 4 degree C upon receipt.; For opened kits: Once the kit is opened, the remaining reagents still need to be stored according to the above storage conditions. In addition, return the unused wells to the foil pouch containing the desiccant pack and reseal along entire edge of zip-seal.

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for FLNC rtu elisa kit

Test Principle: The microtiter plate provided in this kit has been pre-coated with an antibody specific to FLNC. Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody preparation specific to FLNC. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain FLNC, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of FLNC in the samples is then determined by comparing the O.D. of the samples to the standard curve.

NCBI and Uniprot Product Information

• NCBI GI #: 188595687
• NCBI GeneID: 2318
• NCBI Accession #: NP_001120959.1
• NCBI GenBank Nucleotide #: NM_001127487.1
• UniProt Accession #: Q14315; O95303; Q07985; Q9NS12; Q9NYE5; Q9UMR8; Q9Y503; B2ZZ88
• Molecular Weight: 287,281 Da
• NCBI Official Full Name: filamin-C isoform b
• NCBI Official Synonym Full Names: filamin C
• NCBI Official Symbol: FLNC
• NCBI Official Synonym Symbols: ABPA; ABPL; FLN2; MFM5; MPD4; RCM5; CMH26; ABP-280; ABP280A
• NCBI Protein Information: filamin-C
• UniProt Protein Name: Filamin-C
• Protein Family: Filamin
• UniProt Gene Name: FLNC
• UniProt Synonym Gene Names: ABPL; FLN2; FLN-C; FLNc

NCBI Description

This gene encodes one of three related filamin genes, specifically gamma filamin. These filamin proteins crosslink actin filaments into orthogonal networks in cortical cytoplasm and participate in the anchoring of membrane proteins for the actin cytoskeleton. Three functional domains exist in filamin: an N-terminal filamentous actin-binding domain, a C-terminal self-association domain, and a membrane glycoprotein-binding domain. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross-linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers.