IL-1F5/IL-36Ra protein

IL-1F5/IL-36Ra

Cat. Num. AAA8532857

• Gene Names: IL36RN; FIL1; FIL1D; IL1F5; IL1L1; PSORP; IL1HY1; IL1RP3; IL36RA; IL-36Ra; PSORS14; FIL1(DELTA)
• Purity: Greater than 95% as determined by reducing SDS-PAGE.
• Synonyms: IL-1F5/IL-36Ra; Interleukin-36 Receptor Antagonist Protein; FIL1 Delta; IL-1-Related Protein 3; IL-1RP3; Interleukin-1 HY1; IL-1HY1; Interleukin-1 Delta; IL-1 Delta; Interleukin-1 Family Member 5; IL-1F5; Interleukin-1 Receptor Antagonist Homolog 1; IL-1ra Homolog 1; Interleukin-1-Like Protein 1; IL-1L1; IL36RN; FIL1D; IL1F5; IL1HY1; IL1L1; IL1RP3; IL-1F5/IL-36Ra protein

• Host: Human
• Purity/Purification: Greater than 95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized
• Sequence Length: 155

• Expression System: E Coli
• Reconstitution: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.; It is not recommended to reconstitute to a concentration less than 100 mug/ml.; Dissolve the lyophilized protein in ddH2O.; Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
• Endotoxin: Less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.
• Preparation and Storage: Lyophilized protein should be stored at <-20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days.; Aliquots of reconstituted samples are stable at <-20 degree C for 3 months.

Related Product Information for IL-1F5/IL-36Ra protein

Background: Human Interleukin-36 Receptor Antagonist (IL-36RN) is a secreted protein which belongs to the Interleukin 1 cytokine family (IL-1 family). IL-36RN is predominantly expressed in keratinocytes but not in fibroblasts, endothelial cells or melanocytes. IL-36RN is also detected in the spleen, brain leukocyte and macrophage cell types. Increased in lesional psoriasis skin. IL-36RN is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to Interleukin 1 family member 9 (IL1F9). Dysregulated expression of novel agonistic and antagonistic IL-1 family member ligands can promote cutaneous inflammation, revealing potential novel targets for the treatment of inflammatory skin disorders. Human and mouse IL-36RN share 90% sequence identity.
Description: Recombinant Human Interleukin-36 Receptor Antagonist Protein is produced by our E Coli expression system and the target gene encoding Met1-Asp155 is expressed.

NCBI and Uniprot Product Information

• NCBI GI #: 27894310
• NCBI GeneID: 26525
• NCBI Accession #: NP_775262.1
• NCBI GenBank Nucleotide #: NM_173170.1
• UniProt Accession #: Q9UBH0; Q56AT9; Q7RTZ6; A8K2I4
• Molecular Weight: 16,962 Da
• NCBI Official Full Name: interleukin-36 receptor antagonist protein
• NCBI Official Synonym Full Names: interleukin 36 receptor antagonist
• NCBI Official Symbol: IL36RN
• NCBI Official Synonym Symbols: FIL1; FIL1D; IL1F5; IL1L1; PSORP; IL1HY1; IL1RP3; IL36RA; IL-36Ra; PSORS14; FIL1(DELTA)
• NCBI Protein Information: interleukin-36 receptor antagonist protein
• UniProt Protein Name: Interleukin-36 receptor antagonist protein
• UniProt Gene Name: IL36RN
• UniProt Synonym Gene Names: FIL1D; IL1F5; IL1HY1; IL1L1; IL1RP3; IL-1RP3; IL-1HY1; IL-1 delta; IL-1F5; IL-1ra homolog 1; IL-1L1

NCBI Description

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]

Uniprot Description

Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR.