Alpha 1 Acid Glycoprotein Active Protein | ORM1 active protein

Alpha 1 Acid Glycoprotein, Human Plasma

Cat. Num. AAA844022

• Gene Names: ORM1; ORM; AGP1; AGP-A; HEL-S-153w
• Applications: SDS-Page
• Purity: >=95%
• Synonyms: Alpha 1 Acid Glycoprotein; Human Plasma; AGP; Orosomucoid; ORM1 active protein

• Host: Human Plasma
• Purity/Purification: >=95%
• Form/Format: Lyophilized as a salt free solid.; Appearance: Lyophilized
• Sequence Length: 201

• Applicable Applications for ORM1 active protein: SDS-PAGE
• Biological Activity: >= 120 units/mg protein. One unit is defined as the amount of enzyme which will hydrolyze 1 umole of N-tosyl-L-arginine methyl ester in 30 minutes at 37 degree C at pH 8.0.
• Results: >= 120 units/mg protein.
• Unit Definition: One unit is defined as the amount of enzyme which will hydrolyze 1 umole of N-tosyl-L-arginine methyl ester in 30 minutes at 37 degree C at pH 8.0.
• Handling: Centrifuge the vial prior to opening.
• Preparation and Storage: At -20 degree C; Shelf Life: 12 months

Testing Data

Related Product Information for ORM1 active protein

Background: Found in human plasma in concentrations of 55-140 mg per 100 ml. Classical standard glycoprotein for studies on the structure of the oligosaccharide units. Carbohydrate content is 40%. Its biological significance is unknown although it can bind progesterone 15 times as strongly as albumin. Sialic-acid-deficient alpha-1-AG has an affinity for vitamin B-12. Clinically, alpha 1 acid glycoprotein is an acute-phase reactant that together with haptoglobin is an indicator of acute inflammation. The alpha 1 acid glycoprotein: haptoglobin ratio is useful in studies of bone marrow disorders, hemolytic processes and metastases.

Product Categories/Family for ORM1 active protein

Proteins and Enzymes; Native Proteins Proteins and Enzymes; Proteins and Enzymes (A-Z) Proteins and Enzymes; Other Proteins & Enzymes

NCBI and Uniprot Product Information

• NCBI GI #: 167857790
• NCBI GeneID: 5004
• NCBI Accession #: NP_000598.2
• NCBI GenBank Nucleotide #: NM_000607.2
• UniProt Accession #: P02763; Q5T539; Q5U067; Q8TC16; B7ZKQ5; AAB33887
• Molecular Weight: 40.0 kDa
• NCBI Official Full Name: alpha-1-acid glycoprotein 1
• NCBI Official Synonym Full Names: orosomucoid 1
• NCBI Official Symbol: ORM1
• NCBI Official Synonym Symbols: ORM; AGP1; AGP-A; HEL-S-153w
• NCBI Protein Information: alpha-1-acid glycoprotein 1
• UniProt Protein Name: Alpha-1-acid glycoprotein 1
• Protein Family: Alpha-1-acid glycoprotein
• UniProt Gene Name: ORM1
• UniProt Synonym Gene Names: AGP1; AGP 1; OMD 1
• UniProt Entry Name: A1AG1_HUMAN

NCBI Description

This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved in aspects of immunosuppression. [provided by RefSeq, Jul 2008]

Uniprot Description

ORM1: Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction. Belongs to the calycin superfamily. Lipocalin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 9q32

Cellular Component: extracellular space; extracellular region

Molecular Function: protein binding

Biological Process: regulation of immune system process; transport; acute-phase response; inflammatory response