NFkB, p65 Peptide | NKIRAS2 peptide

NFkB, p65, phosphorylated (Ser276), Control Peptide (NF-kB, Nuclear Factor kappa B, RelA)

Cat. Num. AAA658410

• Gene Names: NKIRAS2; KBRAS2; kappaB-Ras2
• Reactivity: Human
• Applications: ELISA
• Purity: Highly Purified; 95% specific peptide
• Synonyms: NFkB; p65; phosphorylated (Ser276); Control Peptide (NF-kB; Nuclear Factor kappa B; RelA); NKIRAS2 peptide

• Reactivity: Human
• Specificity: Block specific interaction of anti-pS276 with pS276 phosphorylated p65.
• Purity/Purification: Highly Purified; 95% specific peptide
• Form/Format: Supplied as a liquid in PBS, 0.1% sodiom azide. No stabilizing proteins added.

• Applicable Applications for NKIRAS2 peptide: ELISA (EL/EIA)
• Application Notes: Suitable for use in ELISA and Antibody Blocking.; Dilution: Antibody Blocking: 1ug per 1ul of antiserum.
• Preparation and Storage: Lyophilized powder may be stored at 4 degree C for short-term only. Stable for 12 months at -20 degree C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20 degree C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for NKIRAS2 peptide

acetyl-Q-L-R-R-P-pS-D-R-E-L-S-C-amide (linear)

Product Categories/Family for NKIRAS2 peptide

Molecular Biology; MB-Transcription Factors

NCBI and Uniprot Product Information

• NCBI GI #: 222136632
• NCBI GeneID: 28511
• NCBI Accession #: NP_001138401.1
• NCBI GenBank Nucleotide #: NM_001144929.1
• UniProt Accession #: Q9NYR9; Q6PK52; Q96KC7; Q9NSX1; A6NCZ5; B3KNN0; B4DNM3
• Molecular Weight: 1.53kD
• NCBI Official Full Name: NF-kappa-B inhibitor-interacting Ras-like protein 2 isoform c
• NCBI Official Synonym Full Names: NFKB inhibitor interacting Ras-like 2
• NCBI Official Symbol: NKIRAS2
• NCBI Official Synonym Symbols: KBRAS2; kappaB-Ras2
• NCBI Protein Information: NF-kappa-B inhibitor-interacting Ras-like protein 2; kappa B-Ras protein 2; I-kappa-B-interacting Ras-like protein 2; NFKB inhibitor interacting Ras-like protein 2
• UniProt Protein Name: NF-kappa-B inhibitor-interacting Ras-like protein 2
• Protein Family: NF-kappa-B inhibitor-interacting Ras-like protein
• UniProt Gene Name: NKIRAS2
• UniProt Synonym Gene Names: KBRAS2; Kappa B-Ras protein 2; KappaB-Ras2
• UniProt Entry Name: KBRS2_HUMAN

Uniprot Description

Function: Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB

By similarity.

Subunit structure: Interacts with both NF-kappa-B inhibitor alpha (NFKBIA) and beta (NFKBIB) in vitro. However, it probably only interacts with NFKBIB in vivo. Ref.1

Subcellular location: Cytoplasm

By similarity.

Tissue specificity: Widely expressed. Ref.1

Domain: In contrast to other members of the Ras family, the members of the KappaB-Ras subfamily do not contain the conserved Gly and Gln residues in positions 13 and 65, which are replaced by Ala and Leu residues, respectively, and are therefore similar to the constitutively active forms of oncogenic forms of Ras. This suggests that members of this family are clearly different from other small GTPases proteins.

Sequence similarities: Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.

Sequence caution: The sequence BAB55006.1 differs from that shown. Reason: Absence of residues from position 133 within an exon that change the frame which is not the result of an alternative splicing.