TISB elisa kit
TISB Colorimetric Cell-Based ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the TIS11 family of early response genes, which are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. This gene is well conserved across species and has a promoter that contains motifs seen in other early-response genes. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Uniprot Description
BRF1: a zinc finger protein that plays an important role in the assembly of the RNA polymerase III initiation factor TFIIIB. Regulates mRNA levels by targeting transcripts containing AREs (AU-rich elements) into the decay pathway. Phosphorylation by Akt apparently generates 14-3-3 binding sites and inhibits BRF1 from promoting mRNA activity.Contains 2 C3H1-type zinc fingers.
Protein type: Transcription factor
Chromosomal Location of Human Ortholog: 14q24.1
Cellular Component: cytoplasm; cytosol; intracellular ribonucleoprotein complex; nucleus; P-body
Molecular Function: 14-3-3 protein binding; DNA binding; DNA binding transcription factor activity; metal ion binding; mRNA binding; protein binding; RNA binding
Biological Process: apoptosis; cell proliferation; cellular response to cAMP; cellular response to epidermal growth factor stimulus; cellular response to fibroblast growth factor stimulus; cellular response to glucocorticoid stimulus; cellular response to hypoxia; cellular response to insulin stimulus; cellular response to peptide hormone stimulus; cellular response to phorbol 13-acetate 12-myristate; cellular response to salt stress; cellular response to transforming growth factor beta stimulus; cellular response to tumor necrosis factor; ERK1 and ERK2 cascade; heart development; MAPK cascade; mesendoderm development; mRNA catabolic process, deadenylation-dependent decay; mRNA catabolic process, deadenylation-independent decay; mRNA processing; mRNA transport; multicellular organism growth; negative regulation of erythrocyte differentiation; negative regulation of mitotic cell cycle phase transition; neural tube development; p38MAPK cascade; phosphoinositide 3-kinase cascade; positive regulation of fat cell differentiation; positive regulation of intracellular mRNA localization; positive regulation of monocyte differentiation; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; proepicardium development; protein kinase B signaling; regulation of B cell differentiation; regulation of gene expression; regulation of keratinocyte apoptotic process; regulation of keratinocyte differentiation; regulation of keratinocyte proliferation; regulation of mRNA 3'-end processing; regulation of mRNA stability; regulation of myoblast differentiation; regulation of stem cell proliferation; regulation of transcription, DNA-templated; response to wounding; T cell differentiation in thymus; vasculogenesis
Research Articles on TISB
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Product Notes
The Human, Mouse, Rat TISB zfp36l1 (Catalog #AAA9500595) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9500595 ELISA Kit recognizes Human, Mouse, Rat TISB. It is sometimes possible for the material contained within the vial of "TISB, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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