PAK3 elisa kit
PAK3 Colorimetric Cell-Based ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a serine-threonine kinase and forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of a non-syndromic form of X-linked intellectual disability. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2017]
Uniprot Description
PAK3: a protein kinase of the STE20 family that regulates synapse formation and plasticity in the hippocampus. May be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Forms an activated complex with GTP-bound P21, CDC2 and RAC1 proteins. Missense and truncation mutations linked to nonsyndromic mental retardation type 30 (MRX30). Two alternatively spliced human isoforms have been reported.
Protein type: EC 2.7.11.1; Kinase, protein; PAKA subfamily; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family
Chromosomal Location of Human Ortholog: Xq23
Cellular Component: cytoplasm; cytosol; endosome; plasma membrane
Molecular Function: ATP binding; MAP kinase kinase activity; metal ion binding; protein binding; protein serine/threonine kinase activity; Rac GTPase binding; SH3 domain binding
Biological Process: activation of MAPK activity; axonogenesis; cell migration; cellular response to organic cyclic compound; dendrite development; ephrin receptor signaling pathway; MAPK cascade; positive regulation of DNA biosynthetic process; positive regulation of fibroblast migration; positive regulation of neuron apoptotic process; regulation of actin filament polymerization; regulation of apoptosis; regulation of axonogenesis; regulation of mitotic cell cycle; Rho protein signal transduction; stimulatory C-type lectin receptor signaling pathway; stress-activated protein kinase signaling pathway; synapse organization; T cell costimulation; T cell receptor signaling pathway
Disease: Mental Retardation, X-linked 30
Research Articles on PAK3
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Product Notes
The Human, Mouse, Rat PAK3 pak3 (Catalog #AAA9500459) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9500459 ELISA Kit recognizes Human, Mouse, Rat PAK3. It is sometimes possible for the material contained within the vial of "PAK3, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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