nNOS elisa kit
nNOS Colorimetric Cell-Based ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that differ in the 5' UTR have been described for this gene but the full-length nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been found for this gene.[provided by RefSeq, Feb 2011]
Uniprot Description
nNOS: nitric oxide synthase 1, neuronal form. Produces nitric oxide which is a messenger molecule with diverse functions and displays many properties of a neurotransmitter in the brain and peripheral nervous system. May be an effector enzyme for the dystrophin complex. Four alternatively spliced isoforms have been described.
Protein type: Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase
Chromosomal Location of Human Ortholog: 12q24.22
Cellular Component: caveola; cytoplasm; cytoskeleton; cytosol; dendritic spine; membrane raft; mitochondrion; nucleoplasm; perinuclear region of cytoplasm; photoreceptor inner segment; plasma membrane; protein complex; ryanodine receptor complex; sarcolemma; sarcoplasmic reticulum; synapse; T-tubule; Z disc
Molecular Function: arginine binding; cadmium ion binding; calmodulin binding; FAD binding; FMN binding; heme binding; ion channel binding; iron ion binding; NADP binding; NADPH-hemoprotein reductase activity; nitric-oxide synthase activity; protein binding; sodium channel regulator activity; tetrahydrobiopterin binding
Biological Process: arginine catabolic process; cell redox homeostasis; cellular response to growth factor stimulus; exogenous drug catabolic process; multicellular organismal response to stress; myoblast fusion; negative regulation of adrenergic receptor signaling pathway involved in heart process; negative regulation of blood pressure; negative regulation of calcium ion transport; negative regulation of calcium ion transport into cytosol; negative regulation of hydrolase activity; negative regulation of potassium ion transport; negative regulation of serotonin uptake; neurotransmitter biosynthetic process; nitric oxide biosynthetic process; nitric oxide mediated signal transduction; peptidyl-cysteine S-nitrosylation; positive regulation of adrenergic receptor signaling pathway involved in heart process; positive regulation of guanylate cyclase activity; positive regulation of histone acetylation; positive regulation of sodium ion transmembrane transport; positive regulation of the force of heart contraction; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; regulation of neurogenesis; regulation of sodium ion transport; response to heat; response to hypoxia; retrograde trans-synaptic signaling by nitric oxide; striated muscle contraction; vasodilation
Disease: Pyloric Stenosis, Infantile Hypertrophic, 1
Research Articles on nNOS
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Product Notes
The Human, Mouse, Rat nNOS nos1 (Catalog #AAA9500427) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9500427 ELISA Kit recognizes Human, Mouse, Rat nNOS. It is sometimes possible for the material contained within the vial of "nNOS, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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