NMDAR1 elisa kit
NMDAR1 Colorimetric Cell-Based ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
Uniprot Description
NMDAR1: a subunit of N-methyl-D-aspartate (NMDA) receptors, members of the glutamate receptor channel superfamily. Possesses high calcium permeability and voltage-dependent sensitivity to magnesium and is modulated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. Mediates neuronal functions in glutamate neurotransmission. Three alternatively-spliced isoforms have been described.
Protein type: Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 9q34.3
Cellular Component: cell junction; cell surface; dendrite; dendritic spine; endoplasmic reticulum; excitatory synapse; integral component of plasma membrane; neuron projection; NMDA selective glutamate receptor complex; plasma membrane; postsynaptic density; postsynaptic density membrane; postsynaptic membrane; synapse; synaptic vesicle; terminal bouton
Molecular Function: calcium channel activity; calcium ion binding; calmodulin binding; extracellular-glutamate-gated ion channel activity; glutamate binding; glutamate-gated calcium ion channel activity; glycine binding; neurotransmitter binding; NMDA glutamate receptor activity; protein binding; protein complex binding; Ras guanyl-nucleotide exchange factor activity; receptor binding; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
Biological Process: adult locomotory behavior; calcium ion homeostasis; calcium-mediated signaling; cation transport; cellular response to amyloid-beta; cerebral cortex development; conditioned taste aversion; ephrin receptor signaling pathway; excitatory postsynaptic potential; ionotropic glutamate receptor signaling pathway; long-term memory; male mating behavior; MAPK cascade; negative regulation of neuron apoptosis; olfactory learning; pons maturation; positive regulation of apoptosis; positive regulation of calcium ion transport into cytosol; positive regulation of excitatory postsynaptic potential; positive regulation of transcription from RNA polymerase II promoter; prepulse inhibition; propylene metabolic process; protein heterotetramerization; regulation of axonogenesis; regulation of dendrite morphogenesis; regulation of long-term neuronal synaptic plasticity; regulation of membrane potential; regulation of molecular function; regulation of respiratory gaseous exchange; regulation of synapse assembly; respiratory gaseous exchange; response to amphetamine; response to ethanol; response to glycine; response to morphine; sensory perception of pain; social behavior; suckling behavior; synaptic transmission, glutamatergic; visual learning
Disease: Mental Retardation, Autosomal Dominant 8
Research Articles on NMDAR1
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Product Notes
The Human, Mouse, Rat NMDAR1 grin1 (Catalog #AAA9500425) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9500425 ELISA Kit recognizes Human, Mouse, Rat NMDAR1. It is sometimes possible for the material contained within the vial of "NMDAR1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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