NF-kappaB p65 elisa kit
Phospho-NF-kappaB p65 (Ser529) Colorimetric Cell-Based ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Uniprot Description
NFkB-p65: a subunit of NF-kappa-B transcription complex, which plays a crucial role in inflammatory and immune responses. The inhibitory effect of I-kappa-B upon NF-kappa-B in the cytoplasm is exerted primarily through the interaction with p65. P65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. There are five NFkB proteins in mammals (RelA/NFkB-p65, RelB, c-Rel, NF-_B1/NFkB-p105, and NF-_B2/NFkB-p100). They form a variety of homodimers and heterodimers, each of which activates its own characteristic set of genes. Three splice-variant isoforms have been identified.
Protein type: DNA-binding; Nuclear receptor co-regulator; Transcription factor
Chromosomal Location of Human Ortholog: 11q13.1
Cellular Component: cytoplasm; cytosol; nuclear chromatin; nucleolus; nucleoplasm; nucleus; transcription factor complex
Molecular Function: actinin binding; activating transcription factor binding; ankyrin repeat binding; chromatin binding; chromatin DNA binding; DNA binding; DNA binding transcription factor activity; histone deacetylase binding; identical protein binding; NF-kappaB binding; phosphate binding; protein binding; protein complex binding; protein heterodimerization activity; protein homodimerization activity; protein kinase binding; protein N-terminus binding; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; transcription factor binding; transcription regulatory region DNA binding; ubiquitin protein ligase binding
Biological Process: acetaldehyde metabolic process; aging; cellular defense response; cellular response to hydrogen peroxide; cellular response to interleukin-1; cellular response to interleukin-6; cellular response to nicotine; cellular response to peptide hormone stimulus; cellular response to tumor necrosis factor; cytokine-mediated signaling pathway; defense response to virus; Fc-epsilon receptor signaling pathway; hair follicle development; inflammatory response; liver development; membrane protein intracellular domain proteolysis; negative regulation of apoptosis; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of insulin receptor signaling pathway; negative regulation of NIK/NF-kappaB signaling; negative regulation of protein catabolic process; negative regulation of protein sumoylation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nucleotide-binding oligomerization domain containing 2 signaling pathway; organ morphogenesis; positive regulation of cell proliferation; positive regulation of chondrocyte differentiation; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of interferon type I production; positive regulation of interleukin-12 biosynthetic process; positive regulation of miRNA metabolic process; positive regulation of NF-kappaB transcription factor activity; positive regulation of NIK/NF-kappaB signaling; positive regulation of Schwann cell differentiation; positive regulation of T cell receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus; positive regulation of transcription, DNA-templated; regulation of DNA-templated transcription in response to stress; regulation of inflammatory response; regulation of NIK/NF-kappaB signaling; regulation of transcription, DNA-templated; response to amino acid; response to cAMP; response to cobalamin; response to drug; response to insulin stimulus; response to morphine; response to muramyl dipeptide; response to muscle stretch; response to organic substance; response to progesterone; response to UV-B; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; viral process
Research Articles on NF-kappaB p65
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Product Notes
The Human, Mouse, Rat NF-kappaB p65 rela (Catalog #AAA9501046) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9501046 ELISA Kit recognizes Human, Mouse, Rat NF-kappaB p65. It is sometimes possible for the material contained within the vial of "NF-kappaB p65, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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