MYF6 elisa kit
MYF6 Colorimetric Cell-Based ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a probable basic helix-loop-helix (bHLH) DNA binding protein involved in muscle differentiation. The encoded protein likely acts as a heterodimer with another bHLH protein. Defects in this gene are a cause of autosomal dominant centronuclear myopathy (ADCNM). [provided by RefSeq, May 2010]
Uniprot Description
Myf-6: Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein. Defects in MYF6 may be a cause of centronuclear myopathy type 3 (CNM3). A congenital muscle disorder characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 12q21.31
Cellular Component: nucleoplasm; nucleus; RNA polymerase II transcription factor complex
Molecular Function: DNA binding transcription factor activity; protein heterodimerization activity; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
Biological Process: muscle cell fate commitment; negative regulation of transcription, DNA-dependent; positive regulation of muscle cell differentiation; positive regulation of myoblast differentiation; positive regulation of skeletal muscle fiber development; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; skeletal muscle tissue development; skeletal muscle tissue regeneration; somitogenesis; transcription from RNA polymerase II promoter
Disease: Myopathy, Centronuclear, 3
Research Articles on MYF6
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Product Notes
The Human, Mouse, Rat MYF6 myf6 (Catalog #AAA9500723) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9500723 ELISA Kit recognizes Human, Mouse, Rat MYF6. It is sometimes possible for the material contained within the vial of "MYF6, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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