MKP-1/2 elisa kit
Phospho-MKP-1/2 (Ser296/318) Colorimetric Cell-Based ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a phosphatase with dual specificity for tyrosine and threonine. The encoded protein can dephosphorylate MAP kinase MAPK1/ERK2, which results in its involvement in several cellular processes. This protein appears to play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. Finally, the encoded protein can make some solid tumors resistant to both chemotherapy and radiotherapy, making it a target for cancer therapy. [provided by RefSeq, Aug 2017]
Uniprot Description
DUSP1: a non-receptor, dual-specificity phosphoprotein phosphatase (DUSP). Different members of the DUSP family show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP1 specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation. It is induced in human skin fibroblasts by oxidative/heat stress and growth factors. Contains 1 rhodanese domain.
Protein type: EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity
Chromosomal Location of Human Ortholog: 5q35.1
Cellular Component: cytoplasm; nucleus
Molecular Function: growth factor binding; MAP kinase tyrosine/serine/threonine phosphatase activity; non-membrane spanning protein tyrosine phosphatase activity; protein binding; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine/threonine phosphatase activity
Biological Process: cellular response to hormone stimulus; endoderm formation; inactivation of MAPK activity; mitotic cell cycle arrest; negative regulation of apoptosis; negative regulation of DNA biosynthetic process; negative regulation of ERK1 and ERK2 cascade; negative regulation of MAP kinase activity; negative regulation of MAPKKK cascade; negative regulation of meiotic cell cycle; peptidyl-threonine dephosphorylation; positive regulation of apoptosis; regulation of apoptosis; regulation of mitotic cell cycle spindle assembly checkpoint; response to calcium ion; response to cAMP; response to estradiol; response to glucocorticoid stimulus; response to hydrogen peroxide; response to light stimulus; response to oxidative stress; response to retinoic acid; response to testosterone stimulus
Research Articles on MKP-1/2
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Product Notes
The Human, Mouse, Rat MKP-1/2 dusp1 (Catalog #AAA9501681) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9501681 ELISA Kit recognizes Human, Mouse, Rat MKP-1/2. It is sometimes possible for the material contained within the vial of "MKP-1/2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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