MAPKAPK2 elisa kit
Phospho-MAPKAPK2 (Thr222) Colorimetric Cell-Based ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
MAPKAPK2: a member of the MAPKAPK family of protein kinases. It is phosphorylated and activated by p38 in response to cytokines, stress and chemotactic factors.MAPKAPK-2 is apparently a direct target of p38 MAPK. HSP27 is one of its in vivo substrates. Two transcript variants encoding two different isoforms have been described.
Protein type: CAMK group; EC 2.7.11.1; Kinase, protein; MAPKAPK family; MAPKAPK subfamily; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 1q32.1
Cellular Component: centrosome; cytoplasm; cytosol; extracellular exosome; nucleoplasm; nucleus
Molecular Function: ATP binding; calcium-dependent protein serine/threonine kinase activity; calmodulin binding; calmodulin-dependent protein kinase activity; mitogen-activated protein kinase binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; signal transducer activity
Biological Process: activation of MAPK activity; cellular response to DNA damage stimulus; inflammatory response; inner ear development; leukotriene metabolic process; macropinocytosis; MAPK cascade; p38MAPK cascade; peptidyl-serine phosphorylation; positive regulation of tumor necrosis factor biosynthetic process; protein amino acid phosphorylation; protein autophosphorylation; Ras protein signal transduction; regulation of cellular response to heat; regulation of interleukin-6 production; regulation of mRNA stability; regulation of tumor necrosis factor production; response to cytokine; response to lipopolysaccharide; toll-like receptor signaling pathway; vascular endothelial growth factor receptor signaling pathway
Research Articles on MAPKAPK2
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Product Notes
The Human, Mouse, Rat MAPKAPK2 mapkapk2 (Catalog #AAA9501196) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9501196 ELISA Kit recognizes Human, Mouse, Rat MAPKAPK2. It is sometimes possible for the material contained within the vial of "MAPKAPK2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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