LIMK1 elisa kit
LIMK1 Colorimetric Cell-Based ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Feb 2011]
Uniprot Description
LIMK1: a TKL kinase of the LISK family which mediates Rho signaling to cytoskeleton. Contains two N-terminal LIM motifs. Phosphorylated and activated by PAK1 and ROCK, downstream effectors of Rho. May be involved in brain development. Phosphorylates and inactivates the actin binding/depolymerizing factor cofilin and induces actin cytoskeletal changes. The LIM domain interacts with the cytoplasmic domain of NRG1. Binds ROCK1. Interacts with slingshot 1. Overexpressed in prostate tumors and prostate and breast cancer cell lines; manipulation of activity correlates with invasiveness in breast and prostate cancer models. Located within the 7q11.2 amplicon associated with metastatic prostate cancer. Loss of one copy of LIMK1 is the likely cause of visuospatial cognition defects seen in small chromosomal deletions associated with dominant Williams-Beuren syndrome Three splice variant have been identified.
Protein type: EC 2.7.11.1; Kinase, protein; LIMK subfamily; LISK family; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group
Chromosomal Location of Human Ortholog: 7q11.23
Cellular Component: cytoplasm; cytosol; focal adhesion; Golgi apparatus; lamellipodium; membrane; neuron projection; nuclear speck; nucleus
Molecular Function: ATP binding; heat shock protein binding; metal ion binding; protein binding; protein heterodimerization activity; protein kinase activity; protein serine/threonine kinase activity; signal transducer activity
Biological Process: actin cytoskeleton organization; Fc-gamma receptor signaling pathway involved in phagocytosis; negative regulation of ubiquitin-protein ligase activity; nervous system development; positive regulation of actin filament bundle assembly; positive regulation of axon extension; positive regulation of stress fiber formation; protein amino acid phosphorylation; Rho protein signal transduction; signal transduction
Disease: Williams-beuren Syndrome
Research Articles on LIMK1
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Product Notes
The Human, Mouse, Rat LIMK1 limk1 (Catalog #AAA9500781) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9500781 ELISA Kit recognizes Human, Mouse, Rat LIMK1. It is sometimes possible for the material contained within the vial of "LIMK1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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