JIP2 elisa kit
JIP2 Colorimetric Cell-Based ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a scaffold protein that is thought to be involved in the regulation of the c-Jun amino-terminal kinase signaling pathway. This protein has been shown to interact with and regulate the activity of MAPK8/JNK1 and MAP2K7/MKK7 kinases. [provided by RefSeq, Jun 2017]
Uniprot Description
MAPK8IP2: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Belongs to the JIP scaffold family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Activator; Protein kinase, regulatory subunit
Chromosomal Location of Human Ortholog: 22q13.33
Cellular Component: cell soma; cytoplasm; postsynaptic density; protein complex
Molecular Function: amyloid-beta binding; kinesin binding; MAP-kinase scaffold activity; protein binding; protein complex binding; protein kinase binding; structural molecule activity
Biological Process: behavioral fear response; dendrite morphogenesis; excitatory postsynaptic potential; JNK cascade; mating behavior; nonassociative learning; positive regulation of stress-activated MAPK cascade; regulation of JNK cascade; regulation of receptor activity; regulation of synaptic transmission, glutamatergic; signal complex assembly; social behavior
Research Articles on JIP2
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Product Notes
The Human, Mouse, Rat JIP2 mapk8ip2 (Catalog #AAA9500828) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9500828 ELISA Kit recognizes Human, Mouse, Rat JIP2. It is sometimes possible for the material contained within the vial of "JIP2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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