NCBI Description
The protein encoded by this gene is the common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defects in this gene have been reported to be associated with protein alveolar proteinosis (PAP). [provided by RefSeq, Jul 2008]
Uniprot Description
CSF2RB: a common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. A type I cytokine family of receptor. Defects are a cause of congenital pulmonary alveolar proteinosis (PAP) [MIM:265120]. PAP is an autosomal recessive fatal respiratory disease.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of Human Ortholog: 22q12.3
Cellular Component: granulocyte macrophage colony-stimulating factor receptor complex; integral component of plasma membrane; intracellular; plasma membrane
Molecular Function: interleukin-3 receptor activity; interleukin-5 receptor activity; protein binding; protein tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity; receptor activity
Biological Process: cellular protein metabolic process; interleukin-3-mediated signaling pathway; interleukin-5-mediated signaling pathway; MAPK cascade; peptidyl-tyrosine phosphorylation; regulation of molecular function; respiratory gaseous exchange; response to lipopolysaccharide; signal transduction
Disease: Surfactant Metabolism Dysfunction, Pulmonary, 5
Product Notes
The Human, Mouse, Rat IL-3Rbeta csf2rb (Catalog #
AAA9501081) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9501081 ELISA Kit recognizes Human, Mouse, Rat IL-3Rbeta.
It is sometimes possible for the material contained within the vial of
"IL-3Rbeta, ELISA Kit" to become dispersed throughout the inside of
the vial, particularly around the seal of said vial, during shipment and storage. We always
suggest centrifuging these vials
to consolidate all of the liquid away from the lid and to the bottom of the vial prior to
opening. Please be advised that
certain products may require dry ice for shipping and that, if this is the case, an
additional dry ice fee may also be
required.
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