HDAC2 elisa kit
HDAC2 Colorimetric Cell-Based ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]
Uniprot Description
HDAC2: a transcriptional regulator of the histone deacetylase family, subfamily 1. Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation plays a role in epigenetic repression and transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
Protein type: Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 6q21
Cellular Component: cytoplasm; ESC/E(Z) complex; nuclear chromatin; nucleoplasm; nucleus; NuRD complex; protein complex; Sin3 complex
Molecular Function: chromatin binding; deacetylase activity; enzyme binding; heat shock protein binding; histone deacetylase activity; histone deacetylase binding; NAD-dependent histone deacetylase activity (H3-K14 specific); NF-kappaB binding; nucleosomal DNA binding; protein binding; protein deacetylase activity; RNA binding; sequence-specific DNA binding; transcription factor binding
Biological Process: ATP-dependent chromatin remodeling; behavioral response to ethanol; blood coagulation; cardiac muscle hypertrophy; cellular response to heat; cellular response to hydrogen peroxide; cellular response to retinoic acid; cellular response to transforming growth factor beta stimulus; chromatin remodeling; circadian regulation of gene expression; dendrite development; embryonic digit morphogenesis; epidermal cell differentiation; histone deacetylation; maintenance of chromatin silencing; negative regulation of apoptosis; negative regulation of DNA binding; negative regulation of MHC class II biosynthetic process; negative regulation of neuron projection development; negative regulation of peptidyl-lysine acetylation; negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; odontogenesis of dentine-containing teeth; positive regulation of cell proliferation; positive regulation of collagen biosynthetic process; positive regulation of epithelial to mesenchymal transition; positive regulation of interleukin-1 production; positive regulation of oligodendrocyte differentiation; positive regulation of proteolysis; positive regulation of receptor biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; positive regulation of tumor necrosis factor production; positive regulation of tyrosine phosphorylation of STAT protein; response to amphetamine; response to caffeine; response to cocaine; response to drug; response to hyperoxia; response to lipopolysaccharide; response to nicotine; transcription, DNA-dependent
