CrkII elisa kit
CrkII Colorimetric Cell-Based ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]
Uniprot Description
CRK: an adaptor protein with an SH2-SH3-SH3 domain structure. Recruits cytoplasmic proteins through SH2-phospho-tyrosine interaction. Phosphorylated by Abl, IGF-IR and EGFR. Phosphorylation induces a change in intramolecular folding and SH2 interactions, causing its rapid dissociation from the tyrosine kinase complex.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis; Oncoprotein
Chromosomal Location of Human Ortholog: 17p13.3
Cellular Component: actin cytoskeleton; cytoplasm; cytosol; extracellular exosome; membrane raft; nucleus; plasma membrane; protein complex
Molecular Function: cytoskeletal protein binding; ephrin receptor binding; insulin-like growth factor receptor binding; phosphotyrosine binding; protein binding; protein phosphorylated amino acid binding; protein self-association; SH2 domain binding; SH3 domain binding; SH3/SH2 adaptor activity
Biological Process: activation of MAPKK activity; cellular response to endothelin; cellular response to insulin-like growth factor stimulus; cellular response to nitric oxide; cellular response to transforming growth factor beta stimulus; ephrin receptor signaling pathway; Fc-gamma receptor signaling pathway involved in phagocytosis; negative regulation of cell motility; negative regulation of natural killer cell mediated cytotoxicity; positive regulation of smooth muscle cell migration; positive regulation of substrate adhesion-dependent cell spreading; regulation of actin cytoskeleton organization; regulation of cell shape; regulation of GTPase activity; regulation of protein binding; regulation of Rac protein signal transduction; regulation of signal transduction; regulation of transcription from RNA polymerase II promoter; response to cholecystokinin; response to hydrogen peroxide; response to yeast; SH2 domain-mediated complex assembly; vascular endothelial growth factor receptor signaling pathway
Research Articles on CrkII
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Product Notes
The Human, Mouse, Rat CrkII crk (Catalog #AAA9500149) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9500149 ELISA Kit recognizes Human, Mouse, Rat CrkII. It is sometimes possible for the material contained within the vial of "CrkII, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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