CBL elisa kit
Phospho-CBL (Tyr774) Colorimetric Cell-Based ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Jul 2016]
Uniprot Description
CBL: an adapter protein that functions as a negative regulator of many signaling pathways that start from receptors at the cell surface. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including PDGFA, EGF and CSF1, and terminates signaling. Participates in signal transduction in hematopoietic cells.
Protein type: Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; Oncoprotein; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 11q23.3
Cellular Component: axon; cytosol; flotillin complex; focal adhesion; growth cone; mast cell granule; membrane raft; nucleus; perinuclear region of cytoplasm; plasma membrane
Molecular Function: cadherin binding; calcium ion binding; DNA binding transcription factor activity; ephrin receptor binding; epidermal growth factor receptor binding; phosphotyrosine binding; protein binding; receptor tyrosine kinase binding; SH3 domain binding; signal transducer activity; ubiquitin-protein transferase activity
Biological Process: cell surface receptor signaling pathway; cellular response to DNA damage stimulus; cellular response to epidermal growth factor stimulus; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; male gonad development; mast cell degranulation; negative regulation of apoptosis; negative regulation of epidermal growth factor receptor activity; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of neuron death; neuron death; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of receptor-mediated endocytosis; protein monoubiquitination; protein polyubiquitination; protein ubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; regulation of transcription, DNA-templated; response to activity; response to antibiotic; response to ethanol; response to gamma radiation; response to starvation; response to testosterone stimulus; transforming growth factor beta receptor signaling pathway
Disease: Juvenile Myelomonocytic Leukemia; Noonan Syndrome-like Disorder With Or Without Juvenile Myelomonocytic Leukemia
Research Articles on CBL
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Product Notes
The Human, Mouse, Rat CBL cbl (Catalog #AAA9501094) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9501094 ELISA Kit recognizes Human, Mouse, Rat CBL. It is sometimes possible for the material contained within the vial of "CBL, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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