ARHGEF2 elisa kit
Phospho-ARHGEF2 (Ser885) Colorimetric Cell-Based ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate rho-dependent signals. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Jun 2009]
Uniprot Description
ARHGEF2: a microtubule-associated guanine nucleotide exchange factor for Rac and Rho GTPases. Mediates cross-talk between microtubules and the actin cytoskeleton. Contains a phorbol esters/diacylglycerol binding and PH domain.
Protein type: GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 1q22
Cellular Component: bicellular tight junction; cell soma; cytoplasm; cytoplasmic vesicle; cytoskeleton; cytosol; dendritic shaft; focal adhesion; Golgi apparatus; microtubule; podosome; postsynaptic density; protein complex; spindle; vesicle
Molecular Function: guanyl-nucleotide exchange factor activity; microtubule binding; protein binding; Rac GTPase binding; Rac guanyl-nucleotide exchange factor activity; Rho GTPase binding; Rho guanyl-nucleotide exchange factor activity; transcription factor binding; zinc ion binding
Biological Process: actin filament organization; asymmetric neuroblast division; cell morphogenesis; cellular hyperosmotic response; cellular response to tumor necrosis factor; establishment of mitotic spindle orientation; G-protein coupled receptor signaling pathway; innate immune response; intracellular protein transport; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress; negative regulation of microtubule depolymerization; negative regulation of neurogenesis; negative regulation of podosome assembly; positive regulation of apoptosis; positive regulation of interleukin-6 production; positive regulation of neuron differentiation; positive regulation of neuron migration; positive regulation of NF-kappaB transcription factor activity; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tumor necrosis factor production; regulation of cell proliferation; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction
Disease: Neurodevelopmental Disorder With Midbrain And Hindbrain Malformations
Research Articles on ARHGEF2
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Product Notes
The Human, Mouse, Rat ARHGEF2 arhgef2 (Catalog #AAA9501382) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9501382 ELISA Kit recognizes Human, Mouse, Rat ARHGEF2. It is sometimes possible for the material contained within the vial of "ARHGEF2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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