MTHFD1 blocking peptide

MTHFD1 Immunizing Peptide

Cat. Num. AAA426610

• Gene Names: MTHFD1; MTHFC; MTHFD
• Reactivity: Human, Mouse, Rat
• Synonyms: MTHFD1; MTHFD1 Immunizing Peptide; methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1; methenyltetrahydrofolate cyclohydrolase; formyltetrahydrofolate synthetase; MTHFC; MTHFD; 5; 10-methylenetetrahydrofolate dehydrogenase; 10-methylenetetrahydrofolate cyclohydrolase; 1; MTHFD1 blocking peptide

• Reactivity: Human, Mouse, Rat
• Form/Format: 100ug of dried peptide
• Sequence: RGDLNDCFIPCTPK
• Sequence Length: 935

• Preparation and Storage: Shipped at ambient temperature, store at -20 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 13699868
• NCBI GeneID: 4522
• NCBI Accession #: NP_005947.2
• NCBI GenBank Nucleotide #: NM_005956.2
• Molecular Weight: 101,559 Da
• NCBI Official Full Name: methylenetetrahydrofolate dehydrogenase 1
• NCBI Official Synonym Full Names: methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1
• NCBI Official Symbol: MTHFD1
• NCBI Official Synonym Symbols: MTHFC; MTHFD
• NCBI Protein Information: C-1-tetrahydrofolate synthase, cytoplasmic
• UniProt Protein Name: C-1-tetrahydrofolate synthase, cytoplasmic
• UniProt Gene Name: MTHFD1
• UniProt Synonym Gene Names: MTHFC; MTHFD; C1-THF synthase
• UniProt Entry Name: C1TC_HUMAN

NCBI Description

This gene encodes a protein that possesses three distinct enzymatic activities, 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase. Each of these activities catalyzes one of three sequential reactions in the interconversion of 1-carbon derivatives of tetrahydrofolate, which are substrates for methionine, thymidylate, and de novo purine syntheses. The trifunctional enzymatic activities are conferred by two major domains, an aminoterminal portion containing the dehydrogenase and cyclohydrolase activities and a larger synthetase domain. [provided by RefSeq, Jul 2008]

Uniprot Description

MTHFD1: an ubiquitous trifunctional enzyme containing two major domains: a N-terminal part, containing methylene-THF dehydrogenase and methenyl-THF cyclohydrolase activities, and a C-terminal part containing a formyl-THF synthetase domain.

Protein type: Carbohydrate Metabolism - glyoxylate and dicarboxylate; Cofactor and Vitamin Metabolism - one carbon pool by folate; EC 1.5.1.5; EC 3.5.4.9; EC 6.3.4.3; Hydrolase; Ligase; Mitochondrial; Oxidoreductase

Chromosomal Location of Human Ortholog: 14q24

Cellular Component: cytoplasm; cytosol; membrane

Molecular Function: formate-tetrahydrofolate ligase activity; methenyltetrahydrofolate cyclohydrolase activity; methylenetetrahydrofolate dehydrogenase (NAD+) activity; methylenetetrahydrofolate dehydrogenase (NADP+) activity; methylenetetrahydrofolate dehydrogenase activity; protein binding

Biological Process: 10-formyltetrahydrofolate biosynthetic process; embryonic neurocranium morphogenesis; embryonic viscerocranium morphogenesis; folic acid metabolic process; heart development; methionine biosynthetic process; methionine metabolic process; neural tube closure; one-carbon compound metabolic process; purine base biosynthetic process; purine nucleotide biosynthetic process; serine family amino acid biosynthetic process; serine family amino acid metabolic process

Disease: Neural Tube Defects, Folate-sensitive