MKNK2 Antibody | anti-MKNK2 antibody

MKNK2 Antibody

Cat. Num. AAA858397

• Gene Names: MKNK2; MNK2; GPRK7
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, ELISA
• Purity: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: MKNK2; MKNK2 Antibody; G protein-coupled receptor kinase 7; GPRK7; MAP kinase interacting serine/threonine kinase 2; MAP kinase signal-integrating kinase 2; MAP kinase-interacting serine/threonine-protein kinase 2; MNK2; Putative map kinase interacting kinase; anti-MKNK2 antibody

• Reactivity: Human, Mouse, Rat
• Specificity: MNK2 antibody detects endogenous levels of total MNK2 protein.
• Purity/Purification: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Sequence Length: 414

• Applicable Applications for anti-MKNK2 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:500~1:3000; ELISA: 1:40000
• Immunogen: The antiserum was produced against synthesized peptide derived from C-terminal of human MNK2.
• Preparation and Storage: Store at-20 degree C for 1 year.

Testing Data

Product Categories/Family for anti-MKNK2 antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

References

Slentz-Kesler K., Genomics 69:63-71(2000). Li Y., Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases. Grimwood J., Nature 428:529-535(2004).

NCBI and Uniprot Product Information

• NCBI GI #: 40018631
• NCBI GeneID: 2872
• NCBI Accession #: NP_060042.2
• NCBI GenBank Nucleotide #: NM_017572.3
• UniProt Accession #: Q9HBH9; Q6GPI3; Q9HBH8; Q9UHR0; Q9Y2N6
• Molecular Weight: – Da
• NCBI Official Full Name: MAP kinase-interacting serine/threonine-protein kinase 2 isoform 1
• NCBI Official Synonym Full Names: MAP kinase interacting serine/threonine kinase 2
• NCBI Official Symbol: MKNK2
• NCBI Official Synonym Symbols: MNK2; GPRK7
• NCBI Protein Information: MAP kinase-interacting serine/threonine-protein kinase 2
• UniProt Protein Name: MAP kinase-interacting serine/threonine-protein kinase 2
• Protein Family: MAP kinase-interacting serine/threonine-protein kinase
• UniProt Gene Name: MKNK2
• UniProt Synonym Gene Names: GPRK7; MNK2; MAPK signal-integrating kinase 2; Mnk2

NCBI Description

This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playing important roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. In addition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) and Cullin2 (Cul2), which are all components of the CBC(VHL) ubiquitin ligase E3 complex. Multiple alternatively spliced transcript variants have been found, but the full-length nature and biological activity of only two variants are determined. These two variants encode distinct isoforms which differ in activity and regulation, and in subcellular localization. [provided by RefSeq, Aug 2011]

Uniprot Description

Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As2O3-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal.