MAX Antibody | anti-MAX antibody

MAX Antibody

Cat. Num. AAA8509773

• Gene Names: MAX; bHLHd4
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, ELISA
• Purity: Affinity-purified fromrabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: MAX; MAX Antibody; MYC-binding novel HLH/LZ protein; MYN; Max protein; anti-MAX antibody

• Reactivity: Human, Mouse, Rat
• Specificity: MAX antibody detects endogenous levels of total MAX protein.
• Purity/Purification: Affinity-purified fromrabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Sequence Length: 87

• Applicable Applications for anti-MAX antibody: Immunohistochemistry (IHC), ELISA (EIA)
• Application Notes: IHC: 1:50-1:100; ELISA: 1:1000
• Immunogen: The antiserum was produced against synthesized peptide derived from Internal of human MAX.
• Preparation and Storage: Store at-20 degree C for 1 year.

Immunohistochemistry (IHC)

(Peptide-+ Immunohistochemistry analysis of paraffin-embedded human brain tissue using MAX antibody.)

References

R Hopewell, Mol. Cell. Biol., Jul 1995; 15: 3470-3478. Gracia Zabala, LANT CELL, Oct 2005; 17: 2619-2632. B Mukherjee, Genes & Dev., Aug 1992; 6: 1480-1492.

NCBI and Uniprot Product Information

• NCBI GI #: 402794193
• NCBI GeneID: 4149
• NCBI Accession #: NP_001257997.1
• NCBI GenBank Nucleotide #: NM_001271068.1
• UniProt Accession #: P61244; P25912; P52163; Q14803; Q96CY8; A6NH73; A8K265; A8K4G4; A8K824
• Molecular Weight: 9,599 Da
• NCBI Official Full Name: protein max isoform g
• NCBI Official Synonym Full Names: MYC associated factor X
• NCBI Official Symbol: MAX
• NCBI Official Synonym Symbols: bHLHd4
• NCBI Protein Information: protein max
• UniProt Protein Name: Protein max
• Protein Family: Maximin
• UniProt Gene Name: MAX
• UniProt Synonym Gene Names: bHLHd4

NCBI Description

The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Mutations of this gene have been reported to be associated with hereditary pheochromocytoma. A pseudogene of this gene is located on the long arm of chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Uniprot Description

Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements.