MAP3K7IP1 Antibody | anti-MAP3K7IP1 antibody

MAP3K7IP1 Antibody

Cat. Num. AAA8516904

• Gene Names: TAB1; 3'-Tab1; MAP3K7IP1
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: Immunogen affinity purified
• Synonyms: MAP3K7IP1; MAP3K7IP1 Antibody; TAB1; 3'-Tab1; anti-MAP3K7IP1 antibody

• Reactivity: Human, Mouse, Rat
• Specificity: MAP3K7IP1 Antibody detects endogenous levels of total MAP3K7IP1
• Purity/Purification: Immunogen affinity purified
• Form/Format: In phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Sequence Length: 504

• Applicable Applications for anti-MAP3K7IP1 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB: 1:500-1:2000; IHC: 1:50-1:200
• Immunogen: Recombinant Protein of human MAP3K7IP1
• Preparation and Storage: Store at-20 degree C for 1 year

Western Blot (WB)

(Western blot analysis of extracts of various celllines, using MAP3K7IP1 antibody.)

Related Product Information for anti-MAP3K7IP1 antibody

The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

NCBI and Uniprot Product Information

• NCBI GI #: 5174703
• NCBI GeneID: 10454
• NCBI Accession #: NP_006107.1
• NCBI GenBank Nucleotide #: NM_006116.2
• UniProt Accession #: Q15750; Q2PP09; Q8IZW2
• Molecular Weight: 54kDa
• NCBI Official Full Name: TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform alpha
• NCBI Official Synonym Full Names: TGF-beta activated kinase 1 (MAP3K7) binding protein 1
• NCBI Official Symbol: TAB1
• NCBI Official Synonym Symbols: 3'-Tab1; MAP3K7IP1
• NCBI Protein Information: TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
• UniProt Protein Name: TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
• UniProt Gene Name: TAB1
• UniProt Synonym Gene Names: MAP3K7IP1; TAK1-binding protein 1

NCBI Description

The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Uniprot Description

May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.CautionLacks several key residues involved in metal-binding and catalytic activity, therefore has lost phosphatase activity.