KLC1 Antibody | anti-KLC1 antibody

KLC1 Antibody

Cat. Num. AAA8516825

• Gene Names: KLC1; KLC; KNS2; KNS2A
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: Immunogen affinity purified
• Synonyms: KLC1; KLC1 Antibody; KLC; KNS2; KNS2A; RP11-73M18.7; RP11-73M18.8; anti-KLC1 antibody

• Reactivity: Human, Mouse, Rat
• Specificity: KLC1 Antibody detects endogenous levels of total KLC1
• Purity/Purification: Immunogen affinity purified
• Form/Format: In phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Sequence Length: 618

• Applicable Applications for anti-KLC1 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB: 1:500-1:2000; IHC: 1:50-1:200
• Immunogen: Recombinant protein of human KLC1
• Preparation and Storage: Store at-20 degree C for 1 year

Western Blot (WB)

(Western blot analysis of extracts of various celllines, using KLC1 antibody.)

Related Product Information for anti-KLC1 antibody

Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named "kinesin 2", this gene is not a member of the kinesin-2/kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature and/or biological validity of most of these variants have not been determined.

NCBI and Uniprot Product Information

• NCBI GI #: 194306559
• NCBI GeneID: 3831
• NCBI Accession #: NP_001123579.1
• NCBI GenBank Nucleotide #: NM_001130107.1
• UniProt Accession #: Q07866; Q7RTM2; Q7RTM3; Q7RTM5; Q7RTP9; Q7RTQ3; Q7RTQ5; Q7RTQ6; Q86SF5; Q86TF5; A6NF62; F8VTM4
• Molecular Weight: 65kDa
• NCBI Official Full Name: kinesin light chain 1 isoform 3
• NCBI Official Synonym Full Names: kinesin light chain 1
• NCBI Official Symbol: KLC1
• NCBI Official Synonym Symbols: KLC; KNS2; KNS2A
• NCBI Protein Information: kinesin light chain 1
• UniProt Protein Name: Kinesin light chain 1
• Protein Family: Kinesin
• UniProt Gene Name: KLC1
• UniProt Synonym Gene Names: KLC; KNS2; KLC 1

NCBI Description

Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named "kinesin 2", this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature and/or biological validity of most of these variants have not been determined. [provided by RefSeq, Jul 2008]

Uniprot Description

Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.CautionIt is uncertain whether Met-1 or Met-5 is the initiator.