IRF2 Antibody | anti-IRF2 antibody

IRF2 Antibody

Cat. Num. AAA853865

• Gene Names: IRF2; IRF-2
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry, ELISA
• Purity: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: IRF2; IRF2 Antibody; Interferon regulatory factor 2; anti-IRF2 antibody

• Reactivity: Human, Mouse, Rat
• Specificity: IRF2 antibody detects endogenous levels of total IRF2 protein.
• Purity/Purification: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Sequence Length: 349

• Applicable Applications for anti-IRF2 antibody: Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
• Application Notes: WB: 1:500~1:1000; IHC: 1:50~1:100; ELISA: 1:20000
• Immunogen: The antiserum was produced against synthesized peptide derived from internal of human IRF2.
• Preparation and Storage: Store at-20 degree C for 1 year.

Testing Data

(Peptide-+)

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue using IRF2 antibody. Western blot analysis of extracts from Jurkat cells and COLO205 cells, using IRF2 antibody.)

Product Categories/Family for anti-IRF2 antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

References

Itoh S., Nucleic Acids Res. 17:8372-8372(1989). Cha Y., J. Biol. Chem. 269:5279-5287(1994). Staal A., J. Cell. Physiol. 185:269-279(2000).

NCBI and Uniprot Product Information

• NCBI GI #: 153082752
• NCBI GeneID: 3660
• NCBI Accession #: NP_002190.2
• NCBI GenBank Nucleotide #: NM_002199.3
• UniProt Accession #: P14316; Q6IAS7; Q96B99; D6RCK5; H0Y8S3
• Molecular Weight: 39,156 Da
• NCBI Official Full Name: interferon regulatory factor 2
• NCBI Official Synonym Full Names: interferon regulatory factor 2
• NCBI Official Symbol: IRF2
• NCBI Official Synonym Symbols: IRF-2
• NCBI Protein Information: interferon regulatory factor 2
• UniProt Protein Name: Interferon regulatory factor 2
• Protein Family: Interferon regulatory factor
• UniProt Gene Name: IRF2
• UniProt Synonym Gene Names: IRF-2

NCBI Description

IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4. [provided by RefSeq, Jul 2008]

Uniprot Description

Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation.