Elk1 Antibody | anti-Elk1 antibody

Elk1 (Ab-389) Antibody

Cat. Num. AAA856641

• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, Immunofluorescence
• Purity: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: Elk1; Elk1 (Ab-389) Antibody; anti-Elk1 antibody

• Reactivity: Human, Mouse, Rat
• Specificity: Elk-1(Ab-389) antibody detects endogenous levels of total Elk-1 protein.
• Purity/Purification: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Sequence Length: 428

• Applicable Applications for anti-Elk1 antibody: Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: IHC: 1:50~1:100; IF: 1:100~1:200
• Immunogen: The antiserum was produced against synthesized non-phosphopeptide derived from human Elk-1 around the phosphorylation site of serine 389 (P-R-SP-P-A).
• Preparation and Storage: Store at-20 degree C for 1 year

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Elk-1 (Ab-389) antibody.)

Product Categories/Family for anti-Elk1 antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

References

Janknecht R, et al. (1993) EMBO J. 12(13): 5097-5104. Marais R, et al. (1993) Cell 73:381-393. Kortenjann M, et al. (1994) Mol Cell Biol. 14:4815-4824. Hill C S, et al. (1995) Cell. 80:199-211. Cavigelli M, et al. (1995) EMBO J. 14:5957-5964.

NCBI and Uniprot Product Information

• NCBI GI #: 166362732
• NCBI GeneID: 2002
• NCBI Accession #: NP_001107595.1
• NCBI GenBank Nucleotide #: NM_001114123.2
• UniProt Accession #: P19419; O75606; O95058; Q969X8; Q9UJM4; B2R7H4
• Molecular Weight: 11,217 Da
• NCBI Official Full Name: ETS domain-containing protein Elk-1 isoform a
• NCBI Official Synonym Full Names: ELK1, ETS transcription factor
• NCBI Official Symbol: ELK1
• NCBI Protein Information: ETS domain-containing protein Elk-1
• UniProt Protein Name: ETS domain-containing protein Elk-1
• Protein Family: ETS domain-containing protein
• UniProt Gene Name: ELK1

NCBI Description

This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. This gene produces multiple isoforms by using alternative translational start codons and by alternative splicing. Related pseudogenes have been identified on chromosomes 7 and 14. [provided by RefSeq, Mar 2012]

Uniprot Description

Transcription factor that binds to purine-rich DNA sequences. Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2. Induces target gene transcription upon JNK-signaling pathway stimulation ().