APBA2 Antibody | anti-APBA2 antibody

APBA2 Antibody

Cat. Num. AAA858444

• Gene Names: APBA2; X11L; MINT2; LIN-10; HsT16821; X11-BETA; D15S1518E; MGC:14091
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, ELISA
• Purity: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: APBA2; APBA2 Antibody; Amyloid beta A4 precursor protein-binding family A member 2; Neuron-specific X11L protein; Neuronal Munc18-1-interacting protein 2; Mint-2; Adapter protein X11beta; anti-APBA2 antibody

• Reactivity: Human, Mouse, Rat
• Specificity: APBA2 antibody detects endogenous levels of total APBA2 protein.
• Purity/Purification: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Sequence Length: 737

• Applicable Applications for anti-APBA2 antibody: Immunohistochemistry (IHC), ELISA (EIA)
• Application Notes: IHC: 1:50-1:100; ELISA: 1:5000
• Immunogen: The antiserum was produced against synthesized peptide derived from internal of human APBA2.
• Preparation and Storage: Store at-20 degree C for 1 year.

Immunohistochemistry (IHC)

(Peptide-+ Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using APBA2 antibody.)

Product Categories/Family for anti-APBA2 antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

References

Tomita S., J. Biol. Chem. 274:2243-2254(1999). Okamoto M., J. Biol. Chem. 272:31459-31464(1997). Lee D.-S., J. Biol. Chem. 275:23134-23138(2000).

NCBI and Uniprot Product Information

• NCBI GI #: 194353992
• NCBI GeneID: 321
• NCBI Accession #: NP_001123886.1
• NCBI GenBank Nucleotide #: NM_001130414.1
• UniProt Accession #: Q99767; O60571; Q5XKC0; E9PGI4
• Molecular Weight: 81,129 Da
• NCBI Official Full Name: amyloid-beta A4 protein-binding family A member 2 isoform b
• NCBI Official Synonym Full Names: amyloid beta precursor protein binding family A member 2
• NCBI Official Symbol: APBA2
• NCBI Official Synonym Symbols: X11L; MINT2; LIN-10; HsT16821; X11-BETA; D15S1518E; MGC:14091
• NCBI Protein Information: amyloid-beta A4 precursor protein-binding family A member 2
• UniProt Protein Name: Amyloid-beta A4 precursor protein-binding family A member 2
• Protein Family: Amyloid beta A4 precursor protein-binding family
• UniProt Gene Name: APBA2
• UniProt Synonym Gene Names: MINT2; X11L; Mint-2

NCBI Description

The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. [provided by RefSeq, Jul 2017]

Uniprot Description

Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta.