Sema-3E and Plexin D1 Receptor Antibody Sampler Kit | Sema-3E antibody sampler kit
Sema-3E and Plexin D1 Receptor
Reactivity
Human, Rat, Mouse
Applications
Western Blot, ELISA
Synonyms
Sema-3E and Plexin D1 Receptor; Sema-3E antibody sampler kit
Reactivity
Human, Rat, Mouse
Form/Format
Rabbit polyclonal antibodies are supplied in phosphate-buffered saline, 50% glycerol, 1mg/ml BSA, and 0.05% sodium azide. The secondary reagents are supplied in the same buffer without azide.
Applicable Applications for Sema-3E antibody sampler kit
Western Blot (WB), ELISA (EIA)
Preparation and Storage
Store all at -20 degree C. Stable for 1 year.
Related Product Information for Sema-3E antibody sampler kit
Kit Summary: The Sema-3E and Plexin D1 Receptor kit can be used to monitor the expression of Sema-3E and its receptor Plexin D1. The kit has an N-terminal region Sema-3E antibody, and Plexin D1 antibodies for detecting two regions in the cytoplasmicdomain and a region in the extracellular Sema domain. The kit also includes secondary reagent for rabbit polyclonalantibody detection.
Background: Plexins are a family of large integral membrane proteins that complex with neuropilins to form semaphorin co-receptors. The extracellular region of plexins contains a semaphorin domain, multiple glycine-rich motifs, and MET-related sequences. The cytoplasmic region contains a Sex/Plexin domain and putative tyrosine phosphorylation sites thatmediate signal transduction after activation. Plexin D1 is a type I transmembrane protein that may be expressed asmultiple isoforms in many cell types, including neurons and endothelial cells. Semaphorin 3E (Sema-3E) and semaphorin4A can bind Plexin D1, and ligand binding leads to phosphorylation of Tyr-1642 and activation of Plexin D1. Sema-3E andits receptor are important for angiogenesis that occurs during blood vessel development and repair. In cancers, Sema-3Eand Plexin D1 are expressed in tumor tissues and cancer cells, and the interaction of these molecules may promotecancer cell migration and metastic spreading. Thus, Plexin D1, and its ligand Sema-3E, may be important regulators ofangiogenesis and metastasis.
Background: Plexins are a family of large integral membrane proteins that complex with neuropilins to form semaphorin co-receptors. The extracellular region of plexins contains a semaphorin domain, multiple glycine-rich motifs, and MET-related sequences. The cytoplasmic region contains a Sex/Plexin domain and putative tyrosine phosphorylation sites thatmediate signal transduction after activation. Plexin D1 is a type I transmembrane protein that may be expressed asmultiple isoforms in many cell types, including neurons and endothelial cells. Semaphorin 3E (Sema-3E) and semaphorin4A can bind Plexin D1, and ligand binding leads to phosphorylation of Tyr-1642 and activation of Plexin D1. Sema-3E andits receptor are important for angiogenesis that occurs during blood vessel development and repair. In cancers, Sema-3Eand Plexin D1 are expressed in tumor tissues and cancer cells, and the interaction of these molecules may promotecancer cell migration and metastic spreading. Thus, Plexin D1, and its ligand Sema-3E, may be important regulators ofangiogenesis and metastasis.
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Product Notes
The Human, Rat, Mouse Sema-3E (Catalog #AAA474572) is an Antibody Sampler Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA474572 Antibody Sampler Kit recognizes Human, Rat, Mouse Sema-3E. AAA Biotech's Sema-3E and Plexin D1 Receptor can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). Researchers should empirically determine the suitability of the Sema-3E for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Sema-3E and Plexin D1 Receptor, Antibody Sampler Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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