Human, Mouse p57 Kip2 ELISA Kit | p57 Kip2 elisa kit

Phospho-p57 Kip2 (Thr310) Colorimetric Cell-Based ELISA Kit

Cat. Num. AAA9501310

• Gene Names: CDKN1C; BWS; WBS; p57; BWCR; KIP2; p57Kip2
• Reactivity: Human, Mouse
• Synonyms: p57 Kip2; Phospho-p57 Kip2 (Thr310) Colorimetric Cell-Based ELISA Kit; CDKN1C; CDN1C; CDNC; Cyclin-dependent kinase inhibitor 1C; Cyclin-dependent kinase inhibitor p57; KIP2; p57 Kip2 elisa kit

• Reactivity: Human, Mouse
• Form/Format: Two 96-Well Plates
• Sequence Length: 316

• Samples: Researchers plate their cell line of choice
• Assay Type: Phospho Cell-Based ELISA
• Sensitivity: >=5000 cells/well
• Reactivity Note: Human: T310, Mouse: T342,
• Detection Method: Colorimetric 450 nm
• Preparation and Storage: Store at 4 degree C.

Product Categories/Family for p57 Kip2 elisa kit

Cell Based ELISA Kit

NCBI and Uniprot Product Information

• NCBI GI #: 4557441
• NCBI GeneID: 1028
• NCBI Accession #: NP_000067.1
• NCBI GenBank Nucleotide #: NM_000076.2
• UniProt Accession #: P49918
• Molecular Weight: 32177
• NCBI Official Full Name: cyclin-dependent kinase inhibitor 1C isoform a
• NCBI Official Synonym Full Names: cyclin dependent kinase inhibitor 1C
• NCBI Official Symbol: CDKN1C
• NCBI Official Synonym Symbols: BWS; WBS; p57; BWCR; KIP2; p57Kip2
• NCBI Protein Information: cyclin-dependent kinase inhibitor 1C
• UniProt Protein Name: Cyclin-dependent kinase inhibitor 1C
• UniProt Gene Name: CDKN1C
• UniProt Synonym Gene Names: KIP2

NCBI Description

This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]

Uniprot Description

p57Kip2: Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non- proliferative state throughout life. Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. High levels are seen in the placenta while low levels are seen in the liver. Belongs to the CDI family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; Inhibitor; Nuclear receptor co-regulator; Tumor suppressor

Chromosomal Location of Human Ortholog: 11p15.4

Cellular Component: cytoplasm; nucleus

Molecular Function: cyclin-dependent protein serine/threonine kinase inhibitor activity; protein binding; protein kinase inhibitor activity

Biological Process: cell cycle arrest; negative regulation of cyclin-dependent protein kinase activity; negative regulation of epithelial cell proliferation; negative regulation of kinase activity; negative regulation of phosphorylation; negative regulation of protein serine/threonine kinase activity; negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-templated; positive regulation of transforming growth factor beta receptor signaling pathway; regulation of mitotic cell cycle

Disease: Beckwith-wiedemann Syndrome; Intrauterine Growth Retardation, Metaphyseal Dysplasia, Adrenal Hypoplasia Congenita, And Genital Anomalies