Testing Data
(The TFact MEF2C DNA-Binding ELISA detects active MEF2C in Hela Nuclear Extract. The Hela cells were grown 3 days in DMEM with 10% FBS and harvested for nuclear extract. The Hela cells were stimulated by serum (20% FBS) before harvest.)
Human, Mouse MEF2C ELISA Kit | MEF2C elisa kit
MEF2C (Phospho-Ser396) TFact DNA-Binding ELISA Kit
Testing Data
(The TFact MEF2C DNA-Binding ELISA detects active MEF2C in Hela Nuclear Extract. The Hela cells were grown 3 days in DMEM with 10% FBS and harvested for nuclear extract. The Hela cells were stimulated by serum (20% FBS) before harvest.)
Testing Data
(The TFact MEF2C DNA-Binding ELISA detects active MEF2C in Hela Nuclear Extract. The Hela cells were grown 3 days in DMEM with 10% FBS and harvested for nuclear extract. The Hela cells were stimulated by serum (20% FBS) before harvest.)
NCBI and Uniprot Product Information
NCBI Description
This locus encodes a member of the MADS box transcription enhancer factor 2 (MEF2) family of proteins, which play a role in myogenesis. The encoded protein, MEF2 polypeptide C, has both trans-activating and DNA binding activities. This protein may play a role in maintaining the differentiated state of muscle cells. Mutations and deletions at this locus have been associated with severe cognitive disability, stereotypic movements, epilepsy, and cerebral malformation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010]
Uniprot Description
MEF2C: transcription factor of the MADS family which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. May be involved in myogenesis, neurogenesis and in the development of cortical architecture. Three splice-variant isoforms have been described.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 5q14.3
Cellular Component: cytoplasm; intracellular membrane-bound organelle; nuclear speck; nucleoplasm; nucleus; postsynapse; protein complex; sarcoplasm
Molecular Function: activating transcription factor binding; AT DNA binding; chromatin binding; DNA binding transcription factor activity; histone deacetylase binding; HMG box domain binding; protein binding; protein heterodimerization activity; transcription regulatory region DNA binding
Biological Process: apoptosis; B cell homeostasis; B cell proliferation; B cell receptor signaling pathway; blood vessel development; blood vessel remodeling; cardiac muscle hypertrophy in response to stress; cardiac ventricle formation; cell morphogenesis involved in neuron differentiation; cellular response to calcium ion; cellular response to fluid shear stress; cellular response to parathyroid hormone stimulus; cellular response to transforming growth factor beta stimulus; cellular response to trichostatin A; chondrocyte differentiation; embryonic viscerocranium morphogenesis; endochondral ossification; epithelial cell proliferation involved in renal tubule morphogenesis; excitatory postsynaptic potential; germinal center formation; glomerulus morphogenesis; heart development; heart looping; humoral immune response; learning and/or memory; MAPK cascade; melanocyte differentiation; monocyte differentiation; muscle cell fate determination; muscle organ development; myotube differentiation; negative regulation of epithelial cell proliferation; negative regulation of gene expression; negative regulation of neuron apoptosis; negative regulation of ossification; negative regulation of transcription from RNA polymerase II promoter; nephron tubule epithelial cell differentiation; nervous system development; neural crest cell differentiation; neuron development; neuron differentiation; neuron migration; osteoblast differentiation; outflow tract morphogenesis; palate development; platelet formation; positive regulation of alkaline phosphatase activity; positive regulation of B cell proliferation; positive regulation of behavioral fear response; positive regulation of bone mineralization; positive regulation of cardiac muscle cell differentiation; positive regulation of cardiac muscle cell proliferation; positive regulation of cell proliferation in bone marrow; positive regulation of gene expression; positive regulation of macrophage apoptotic process; positive regulation of muscle cell differentiation; positive regulation of myoblast differentiation; positive regulation of neuron differentiation; positive regulation of osteoblast differentiation; positive regulation of protein homodimerization activity; positive regulation of skeletal muscle cell differentiation; positive regulation of skeletal muscle tissue development; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; primary heart field specification; regulation of AMPA receptor activity; regulation of germinal center formation; regulation of megakaryocyte differentiation; regulation of neuron apoptosis; regulation of neurotransmitter secretion; regulation of NMDA receptor activity; regulation of synapse assembly; regulation of synaptic activity; regulation of synaptic plasticity; regulation of synaptic transmission, glutamatergic; regulation of transcription, DNA-templated; secondary heart field specification; sinoatrial valve morphogenesis; skeletal muscle tissue development; smooth muscle cell differentiation; transcription from RNA polymerase II promoter; ventricular cardiac muscle cell differentiation
Disease: Mental Retardation, Autosomal Dominant 20
Research Articles on MEF2C
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Product Notes
The Human, Mouse MEF2C mef2c (Catalog #AAA9502254) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9502254 ELISA Kit recognizes Human, Mouse MEF2C. It is sometimes possible for the material contained within the vial of "MEF2C, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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