anti-Human, Mouse RBM5 Antibody | anti-RBM5 antibody

RBM5 Antibody

Cat. Num. AAA858102

• Gene Names: RBM5; G15; H37; RMB5; LUCA15
• Reactivity: Human, Mouse
• Applications: Western Blot, ELISA
• Purity: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: RBM5; RBM5 Antibody; G15; H37; LUCA15; RMB5; RNA binding motif protein 5; anti-RBM5 antibody

• Reactivity: Human, Mouse
• Specificity: RBM5 antibody detects endogenous levels of total RBM5 protein.
• Purity/Purification: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Sequence Length: 815

• Applicable Applications for anti-RBM5 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:500-1:1000; ELISA: 1:10000
• Immunogen: The antiserum was produced against synthesized peptide derived from internal of human RBM5.
• Preparation and Storage: Store at-20 degree C for 1 year.

Testing Data

(Peptide-+)

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of paraffin-embedded human brain tissue using RBM5 antibody. Western blot analysis of extracts from HUVEC cells, using RBM5 antibody.)

Product Categories/Family for anti-RBM5 antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

References

Bader S., Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases. Timmer T., Genomics 60:238-240(1999). Oh J.J., Nucleic Acids Res. 27:4008-4017(1999).

NCBI and Uniprot Product Information

• NCBI GI #: 5032031
• NCBI GeneID: 10181
• NCBI Accession #: NP_005769.1
• NCBI GenBank Nucleotide #: NM_005778.3
• UniProt Accession #: P52756; Q93021; Q9BU14; Q9HDA6; Q9UKY8; Q9UL24; B2RA45; B4DM16; B4DMF9; B4DZ63
• Molecular Weight: 17,891 Da
• NCBI Official Full Name: RNA-binding protein 5
• NCBI Official Synonym Full Names: RNA binding motif protein 5
• NCBI Official Symbol: RBM5
• NCBI Official Synonym Symbols: G15; H37; RMB5; LUCA15
• NCBI Protein Information: RNA-binding protein 5
• UniProt Protein Name: RNA-binding protein 5
• Protein Family: RNA-binding protein
• UniProt Gene Name: RBM5

NCBI Description

This gene is a candidate tumor suppressor gene which encodes a nuclear RNA binding protein that is a component of the spliceosome A complex. The encoded protein plays a role in the induction of cell cycle arrest and apoptosis through pre-mRNA splicing of multiple target genes including the tumor suppressor protein p53. This gene is located within the tumor suppressor region 3p21.3, and may play a role in the inhibition of tumor transformation and progression of several malignancies including lung cancer. [provided by RefSeq, Oct 2011]

Uniprot Description

Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate apoptosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis.