anti-Human, Mouse KCNQ4 Antibody | anti-KCNQ4 antibody

KCNQ4 Antibody

Cat. Num. AAA853689

• Gene Names: KCNQ4; DFNA2; KV7.4; DFNA2A
• Reactivity: Human, Mouse
• Applications: Western Blot, ELISA
• Purity: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: KCNQ4; KCNQ4 Antibody; Potassium voltage-gated channel subfamily KQT member 4; Voltage-gated potassium channel subunit Kv7.4; Potassium channel subunit alpha KvLQT4; KQT-like 4; anti-KCNQ4 antibody

• Reactivity: Human, Mouse
• Specificity: KCNQ4 antibody detects endogenous levels of total KCNQ4 protein.
• Purity/Purification: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Sequence Length: 695

• Applicable Applications for anti-KCNQ4 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:500~1:1000; ELISA: 1:5000
• Immunogen: The antiserum was produced against synthesized peptide derived from C-terminal of human KCNQ4.
• Preparation and Storage: Store at-20 degree C for 1 year.

Western Blot (WB)

(Western blot analysis of extracts from HuvEc cells, using KCNQ4 antibody. For Research Use Only)

Product Categories/Family for anti-KCNQ4 antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

References

Kubisch C., Cell 96:437-446(1999). Gregory S.G., Nature 441:315-321(2006). Selyanko A.A., J. Physiol. (Lond.) 522:349-355(2000).

NCBI and Uniprot Product Information

• NCBI GI #: 26638653
• NCBI GeneID: 9132
• NCBI Accession #: NP_004691.2
• NCBI GenBank Nucleotide #: NM_004700.3
• UniProt Accession #: P56696; O96025
• Molecular Weight: 71,196 Da
• NCBI Official Full Name: potassium voltage-gated channel subfamily KQT member 4 isoform a
• NCBI Official Synonym Full Names: potassium voltage-gated channel subfamily Q member 4
• NCBI Official Symbol: KCNQ4
• NCBI Official Synonym Symbols: DFNA2; KV7.4; DFNA2A
• NCBI Protein Information: potassium voltage-gated channel subfamily KQT member 4
• UniProt Protein Name: Potassium voltage-gated channel subfamily KQT member 4
• Protein Family: Potassium voltage-gated channel subfamily
• UniProt Gene Name: KCNQ4

NCBI Description

The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association with the protein encoded by the KCNQ3 gene. Defects in this gene are a cause of nonsyndromic sensorineural deafness type 2 (DFNA2), an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinic receptors.